PDB entry 3c09

View 3c09 on RCSB PDB site
Description: Crystal structure the Fab fragment of matuzumab (Fab72000) in complex with domain III of the extracellular region of EGFR
Class: immune system/transferase
Keywords: cell surface receptor, glycoprotein, antigen, antibody complex, fab fragment, antitumor, drug immune system/transferase complex
Deposited on 2008-01-18, released 2008-04-15
The last revision prior to the SCOP 1.75 freeze date was dated 2008-04-15, with a file datestamp of 2008-04-11.
Experiment type: XRAY
Resolution: 3.2 Å
R-factor: 0.245
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Epidermal growth factor receptor
    Species: HOMO SAPIENS
    Gene: EGFR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00533 (5-End)
      • expression tag (3-4)
    Domains in SCOP 1.75: d3c09a1, d3c09a2
  • Chain 'B':
    Compound: Matuzumab Fab Light chain
    Species: homo sapiens, mus musculus
    Database cross-references and differences (RAF-indexed):
    • PDB 3C09 (0-End)
  • Chain 'C':
    Compound: Matuzumab Fab Heavy chain
    Species: homo sapiens, mus musculus
    Database cross-references and differences (RAF-indexed):
    • PDB 3C09 (0-End)
    Domains in SCOP 1.75: d3c09c1, d3c09c2
  • Chain 'D':
    Compound: Epidermal growth factor receptor
    Species: HOMO SAPIENS
    Gene: EGFR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00533 (5-End)
      • expression tag (3-4)
    Domains in SCOP 1.75: d3c09d1, d3c09d2
  • Chain 'H':
    Compound: Matuzumab Fab Heavy chain
    Species: homo sapiens, mus musculus
    Database cross-references and differences (RAF-indexed):
    • PDB 3C09 (0-End)
    Domains in SCOP 1.75: d3c09h1, d3c09h2
  • Chain 'L':
    Compound: Matuzumab Fab Light chain
    Species: homo sapiens, mus musculus
    Database cross-references and differences (RAF-indexed):
    • PDB 3C09 (0-End)
  • Heterogens: NAG, BMA, MAN

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3c09A (A:)
leekkvcngigigefkdslsinatnikhfknctsisgdlhilpvafrgdsfthtppldpq
eldilktvkeitgflliqawpenrtdlhafenleiirgrtkqhgqfslavvslnitslgl
rslkeisdgdviisgnknlcyantinwkklfgtsgqktkiisnrgensckatgqvchalc
spegcwgpeprdcvscrnvsrgrecvdkhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3c09A (A:)
kkvcngigigefkdslsinatnikhfknctsisgdlhilpvafrgdsfthtppldpqeld
ilktvkeitgflliqawpenrtdlhafenleiirgrtkqhgqfslavvslnitslglrsl
keisdgdviisgnknlcyantinwkklfgtsgqktkiisnrgensckatgqvchalcspe
gcwgpeprdcv

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3c09C (C:)
qvqlvqsgaevkkpgasvkvsckasgytftshwmhwvrqapgqglewigefnpsngrtny
nekfkskatmtvdtstntaymelsslrsedtavyycasrdydyagryfdywgqgtlvtvs
sastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqs
sglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepks

    Sequence, based on observed residues (ATOM records): (download) 
    >3c09C (C:)
qvqlvqsgaevkkpgasvkvsckasgytftshwmhwvrqapgqglewigefnpsngrtny
nekfkskatmtvdtstntaymelsslrsedtavyycasrdydyagryfdywgqgtlvtvs
sastkgpsgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvtvyicnvn
hkpsntkvdkk

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3c09D (D:)
leekkvcngigigefkdslsinatnikhfknctsisgdlhilpvafrgdsfthtppldpq
eldilktvkeitgflliqawpenrtdlhafenleiirgrtkqhgqfslavvslnitslgl
rslkeisdgdviisgnknlcyantinwkklfgtsgqktkiisnrgensckatgqvchalc
spegcwgpeprdcvscrnvsrgrecvdkhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3c09D (D:)
kkvcngigigefkdslsinatnikhfknctsisgdlhilpvafrgdsfthtppldpqeld
ilktvkeitgflliqawpenrtdlhafenleiirgrtkqhgqfslavvslnitslglrsl
keisdgdviisgnknlcyantinwkklfgtsgqktkiisnrgensckatgqvchalcspe
gcwgpeprdcv

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >3c09H (H:)
qvqlvqsgaevkkpgasvkvsckasgytftshwmhwvrqapgqglewigefnpsngrtny
nekfkskatmtvdtstntaymelsslrsedtavyycasrdydyagryfdywgqgtlvtvs
sastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqs
sglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepks

    Sequence, based on observed residues (ATOM records): (download) 
    >3c09H (H:)
qvqlvqsgaevkkpgasvkvsckasgytftshwmhwvrqapgqglewigefnpsngrtny
nekfkskatmtvdtstntaymelsslrsedtavyycasrdydyagryfdywgqgtlvtvs
sastkgpsvfplapsgtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglysl
ssvvtvpssslgtqtyicnvnhkpsntkvdkkvepk

  • Chain 'L':
    No sequence available.