PDB entry 3buo

View 3buo on RCSB PDB site
Description: Crystal structure of c-Cbl-TKB domain complexed with its binding motif in EGF receptor'
Class: ligase/signaling protein
Keywords: Cbl, TKB, ligase, signal transduction, proto-oncogene, complex, Alternative splicing, Anti-oncogene, ATP-binding, Cell cycle, Disease mutation, Glycoprotein, Kinase, Membrane, Nucleotide-binding, Phosphoprotein, Polymorphism, Receptor, Secreted, Transferase, Transmembrane, Tyrosine-protein kinase, Ubl conjugation, Calcium, Cytoplasm, Metal-binding, SH2 domain, Ubl conjugation pathway, Zinc, Zinc-finger, LIGASE/SIGNALING PROTEIN COMPLEX
Deposited on 2008-01-03, released 2008-02-26
The last revision prior to the SCOP 1.75 freeze date was dated 2008-03-18, with a file datestamp of 2008-03-14.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.231
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 13-meric peptide from Epidermal growth factor receptor
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: E3 ubiquitin-protein ligase CBL
    Species: HOMO SAPIENS
    Gene: CBL, CBL2, RNF55
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d3buob1, d3buob2, d3buob3
  • Chain 'C':
    Compound: 13-meric peptide from Epidermal growth factor receptor
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: E3 ubiquitin-protein ligase CBL
    Species: HOMO SAPIENS
    Gene: CBL, CBL2, RNF55
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d3buod1, d3buod2, d3buod3
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3buoB (B:)
gsliglmkdafqphhhhhhhlsphppgtvdkkmvekcwklmdkvvrlcqnpklalknspp
yildllpdtyqhlrtilsryegkmetlgeneyfrvfmenlmkktkqtislfkegkermye
ensqprrnltklslifshmlaelkgifpsglfqgdtfritkadaaefwrkafgektivpw
ksfrqalhevhpissgleamalkstidltcndyisvfefdiftrlfqpwssllrnwnsla
vthpgymafltydevkarlqkfihkpgsyifrlsctrlgqwaigyvtadgnilqtiphnk
plfqalidgfregfylfpdgrnqnpdltg

    Sequence, based on observed residues (ATOM records): (download) 
    >3buoB (B:)
pgtvdkkmvekcwklmdkvvrlcqnpklalknsppyildllpdtyqhlrtilsryegkme
tlgeneyfrvfmenlmkktkqtislfkegkermyeensqprrnltklslifshmlaelkg
ifpsglfqgdtfritkadaaefwrkafgektivpwksfrqalhevhpissgleamalkst
idltcndyisvfefdiftrlfqpwssllrnwnslavthpgymafltydevkarlqkfihk
pgsyifrlsctrlgqwaigyvtadgnilqtiphnkplfqalidgfregfylfpdgrnqnp
dltg

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3buoD (D:)
gsliglmkdafqphhhhhhhlsphppgtvdkkmvekcwklmdkvvrlcqnpklalknspp
yildllpdtyqhlrtilsryegkmetlgeneyfrvfmenlmkktkqtislfkegkermye
ensqprrnltklslifshmlaelkgifpsglfqgdtfritkadaaefwrkafgektivpw
ksfrqalhevhpissgleamalkstidltcndyisvfefdiftrlfqpwssllrnwnsla
vthpgymafltydevkarlqkfihkpgsyifrlsctrlgqwaigyvtadgnilqtiphnk
plfqalidgfregfylfpdgrnqnpdltg

    Sequence, based on observed residues (ATOM records): (download) 
    >3buoD (D:)
pgtvdkkmvekcwklmdkvvrlcqnpklalknsppyildllpdtyqhlrtilsryegkme
tlgeneyfrvfmenlmkktkqtislfkegkermyeensqprrnltklslifshmlaelkg
ifpsglfqgdtfritkadaaefwrkafgektivpwksfrqalhevhpissgleamalkst
idltcndyisvfefdiftrlfqpwssllrnwnslavthpgymafltydevkarlqkfihk
pgsyifrlsctrlgqwaigyvtadgnilqtiphnkplfqalidgfregfylfpdgrnqnp
dltg