PDB entry 3bu5

View 3bu5 on RCSB PDB site
Description: Crystal structure of the insulin receptor kinase in complex with IRS2 KRLB peptide and ATP
Class: transferase
Keywords: IRK, KRLB, IRS2, ATP, insulin receptor, peptide, substrate, Alternative splicing, ATP-binding, Carbohydrate metabolism, Cleavage on pair of basic residues, Diabetes mellitus, Disease mutation, Glycoprotein, Kinase, Membrane, Nucleotide-binding, Phosphoprotein, Polymorphism, Transferase, Transmembrane, Tyrosine-protein kinase, Transducer
Deposited on 2007-12-31, released 2008-02-19
The last revision prior to the SCOPe 2.05 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.196
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: insulin receptor subunit beta
    Species: Homo sapiens [TaxId:9606]
    Gene: INSR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P06213 (Start-305)
      • variant (273)
    Domains in SCOPe 2.05: d3bu5a_
  • Chain 'B':
    Compound: Insulin receptor substrate 2
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
  • Heterogens: MG, ATP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3bu5A (A:)
vfpssvyvpdewevsrekitllrelgqgsfgmvyegnardiikgeaetrvavktvnesas
lrerieflneasvmkgftchhvvrllgvvskgqptlvvmelmahgdlksylrslrpeaen
npgrppptlqemiqmaaeiadgmaylnakkfvhrdlaarncmvahdftvkigdfgmtrdi
yetdyyrkggkgllpvrwmapeslkdgvfttssdmwsfgvvlweitslaeqpyqglsneq
vlkfvmdggyldqpdncpervtdlmrmcwqfnpnmrptfleivnllkddlhpsfpevsff
hseenk

    Sequence, based on observed residues (ATOM records): (download) 
    >3bu5A (A:)
dewevsrekitllrelgqgmvyegnardiikgeaetrvavktvnesaslrerieflneas
vmkgftchhvvrllgvvskgqptlvvmelmahgdlksylrslrpeaennpgrppptlqem
iqmaaeiadgmaylnakkfvhrdlaarncmvahdftvkigdfgmtrdiyetdyyrkggkg
llpvrwmapeslkdgvfttssdmwsfgvvlweitslaeqpyqglsneqvlkfvmdggyld
qpdncpervtdlmrmcwqfnpnmrptfleivnllkddlhpsfpevsffhseenk

  • Chain 'B':
    No sequence available.