PDB entry 3br9

View 3br9 on RCSB PDB site
Description: Crystal Structure of HCV NS5B Polymerase with a Novel Pyridazinone Inhibitor
Class: transferase
Keywords: PROTEIN-LIGAND COMPLEX, METAL-BINDING, NUCLEOTIDE-BINDING, NUCLEOTIDYLTRANSFERASE, RIBONUCLEOPROTEIN, RNA REPLICATION, RNA-BINDING, RNA-DIRECTED RNA POLYMERASE, TRANSCRIPTION, TRANSCRIPTION REGULATION, TRANSFERASE, CYTOPLASM, HOST-VIRUS INTERACTION, ANTIVIRAL, VIRAL NUCLEOPROTEIN, hydrolase
Deposited on 2007-12-21, released 2008-12-23
The last revision prior to the SCOPe 2.08 freeze date was dated 2008-12-23, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.195
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: RNA-directed RNA polymerase
    Species: Hepatitis C virus [TaxId:11103]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P26663 (0-End)
      • engineered (543)
    Domains in SCOPe 2.08: d3br9a_
  • Chain 'B':
    Compound: RNA-directed RNA polymerase
    Species: Hepatitis C virus [TaxId:11103]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P26663 (0-End)
      • engineered (543)
    Domains in SCOPe 2.08: d3br9b_
  • Heterogens: DEY, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3br9A (A:)
    smsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvl
    ddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhih
    svwkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
    tlpqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiy
    qccdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkas
    aacraaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydl
    elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlw
    armilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspg
    einrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpip
    aasqldlsgwfvagysggdiyhslsrarprlehhhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >3br9A (A:)
    smsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvl
    ddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhih
    svwkdlledtvtpidttimaknevfcvqrkparlivfpdlgvrvcekmalydvvstlpqv
    vmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiyqccdl
    apearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkasaacra
    aklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydlelits
    cssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlwarmil
    mthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspgeinrv
    asclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpipaasql
    dlsgwfvagysggdiyh
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >3br9B (B:)
    smsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvl
    ddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhih
    svwkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
    tlpqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiy
    qccdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkas
    aacraaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydl
    elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlw
    armilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspg
    einrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpip
    aasqldlsgwfvagysggdiyhslsrarprlehhhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >3br9B (B:)
    smsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvl
    ddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhih
    svwkdlledtvtpidttimaknevfcvqrkparlivfpdlgvrvcekmalydvvstlpqv
    vmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiyqccdl
    apearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkasaacra
    aklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydlelits
    cssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlwarmil
    mthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspgeinrv
    asclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpipaasql
    dlsgwfvagysggdiyh