PDB entry 3bps

View 3bps on RCSB PDB site
Description: PCSK9:EGF-A complex
Class: HYDROLASE/Lipid Transport
Keywords: PCSK9, LDL receptor, Autocatalytic cleavage, Cholesterol metabolism, Disease mutation, Glycoprotein, Hydrolase, Lipid metabolism, Phosphoprotein, Protease, Secreted, Serine protease, Steroid metabolism, Zymogen, Coated pit, EGF-like domain, Endocytosis, Host-virus interaction, Lipid transport, Membrane, Transmembrane, Transport, HYDROLASE-Lipid Transport COMPLEX
Deposited on 2007-12-19, released 2008-02-12
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.41 Å
R-factor: 0.205
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Proprotein convertase subtilisin/kexin type 9
    Species: Homo sapiens [TaxId:9606]
    Gene: PCSK9, NARC1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3bpsa1
  • Chain 'E':
    Compound: low-density lipoprotein receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: LDLR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01130 (3-End)
      • expression tag (2)
    Domains in SCOPe 2.08: d3bpse2, d3bpse3
  • Chain 'P':
    Compound: Proprotein convertase subtilisin/kexin type 9
    Species: Homo sapiens [TaxId:9606]
    Gene: PCSK9, NARC1
    Database cross-references and differences (RAF-indexed):
  • Heterogens: CA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3bpsA (A:)
sipwnleritppryradeyqppdggslvevylldtsiqsdhreiegrvmvtdfenvpeed
gtrfhrqaskcdshgthlagvvsgrdagvakgasmrslrvlncqgkgtvsgtliglefir
ksqlvqpvgplvvllplaggysrvlnaacqrlaragvvlvtaagnfrddaclyspasape
vitvgatnaqdqpvtlgtlgtnfgrcvdlfapgediigassdcstcfvsqsgtsqaaahv
agiaammlsaepeltlaelrqrlihfsakdvineawfpedqrvltpnlvaalppsthgag
wqlfcrtvwsahsgptrmataiarcapdeellscssfsrsgkrrgermeaqggklvcrah
nafggegvyaiarccllpqancsvhtappaeasmgtrvhchqqghvltgcsshwevedlg
thkppvlrprgqpnqcvghreasihascchapgleckvkehgipapqeqvtvaceegwtl
tgcsalpgtshvlgayavdntcvvrsrdvsttgstseeavtavaiccrsrhlaqasqelq

    Sequence, based on observed residues (ATOM records): (download) 
    >3bpsA (A:)
sipwnleritppryradeyqgslvevylldtsiqsdhreiegrvmvtdfenvpeeaskcd
shgthlagvvsgrdagvakgasmrslrvlncqgkgtvsgtliglefirksqlvqpvgplv
vllplaggysrvlnaacqrlaragvvlvtaagnfrddaclyspasapevitvgatnaqdq
pvtlgtlgtnfgrcvdlfapgediigassdcstcfvsqsgtsqaaahvagiaammlsaep
eltlaelrqrlihfsakdvineawfpedqrvltpnlvaalppsthwqlfcrtvwsahsgp
trmataiarcapdeellscssfsrsgkrrgermeaqggklvcrahnafggegvyaiarcc
llpqhapgleckvkehgipapqeqvtvaceegwtltgcsalpgtshvlgayavdntcvvr
srdavtavaiccrsr

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >3bpsE (E:)
gamgtnecldnnggcshvcndlkigyeclcpdgfqlvaqrrcedidecqdpdtcsqlcvn
leggykcqceegfqldphtkack

    Sequence, based on observed residues (ATOM records): (download) 
    >3bpsE (E:)
mgtnecldnnggcshvcndlkigyeclcpdgfqlvaqrrce

  • Chain 'P':
    No sequence available.