PDB entry 3bpr

View 3bpr on RCSB PDB site
Description: Crystal structure of catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor C52
Deposited on 2007-12-19, released 2008-01-29
The last revision was dated 2010-05-19, with a file datestamp of 2010-05-14.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.275
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Proto-oncogene tyrosine-protein kinase MER
    Species: Homo sapiens [TaxId:9606]
    Gene: MERTK, MER
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Proto-oncogene tyrosine-protein kinase MER
    Species: Homo sapiens [TaxId:9606]
    Gene: MERTK, MER
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Proto-oncogene tyrosine-protein kinase MER
    Species: Homo sapiens [TaxId:9606]
    Gene: MERTK, MER
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Proto-oncogene tyrosine-protein kinase MER
    Species: Homo sapiens [TaxId:9606]
    Gene: MERTK, MER
    Database cross-references and differences (RAF-indexed):
  • Heterogens: NA, CL, OLP, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >3bprA (A:)
mgsshhhhhhssglvprgseelqnkledvvidrnllilgkilgegefgsvmegnlkqedg
tslkvavktmkldnssqreieeflseaacmkdfshpnvirllgvciemssqgipkpmvil
pfmkygdlhtyllysrletgpkhiplqtllkfmvdialgmeylsnrnflhrdlaarncml
rddmtvcvadfglskkiysgdyyrqgriakmpvkwiaiesladrvytsksdvwafgvtmw
eiatrgmtpypgvqnhemydyllhghrlkqpedcldelyeimyscwrtdpldrptfsvlr
lqleklleslpdv

    Sequence, based on observed residues (ATOM records):
    >3bprA (A:)
nkledvvidrnllilgkilgegefgsvmegnlkqedgtslkvavktmkreieeflseaac
mkdfshpnvirllgvciemsspmvilpfmkygdlhtyllysrletgpkhiplqtllkfmv
dialgmeylsnrnflhrdlaarncmlrddmtvcvadfglspvkwiaiesladrvytsksd
vwafgvtmweiatrgmtpypgvqnhemydyllhghrlkqpedcldelyeimyscwrtdpl
drptfsvlrlqleklleslpd

  • Chain 'B':
    Sequence, based on SEQRES records:
    >3bprB (B:)
mgsshhhhhhssglvprgseelqnkledvvidrnllilgkilgegefgsvmegnlkqedg
tslkvavktmkldnssqreieeflseaacmkdfshpnvirllgvciemssqgipkpmvil
pfmkygdlhtyllysrletgpkhiplqtllkfmvdialgmeylsnrnflhrdlaarncml
rddmtvcvadfglskkiysgdyyrqgriakmpvkwiaiesladrvytsksdvwafgvtmw
eiatrgmtpypgvqnhemydyllhghrlkqpedcldelyeimyscwrtdpldrptfsvlr
lqleklleslpdv

    Sequence, based on observed residues (ATOM records):
    >3bprB (B:)
kledvvidrnllilgkilgeefgsvmegnlkqedgtslkvavktmklieeflseaacmkd
fshpnvirllgvciempmvilpfmkygdlhtyllysrletgpkhiplqtllkfmvdialg
meylsnrnflhrdlaarncmlrddmtvcvadfglspvkwiaiesladrvytsksdvwafg
vtmweiatrgmtpypgvqnhemydyllhghrlkqpedcldelyeimyscwrtdpldrptf
svlrlqleklleslpd

  • Chain 'C':
    Sequence, based on SEQRES records:
    >3bprC (C:)
mgsshhhhhhssglvprgseelqnkledvvidrnllilgkilgegefgsvmegnlkqedg
tslkvavktmkldnssqreieeflseaacmkdfshpnvirllgvciemssqgipkpmvil
pfmkygdlhtyllysrletgpkhiplqtllkfmvdialgmeylsnrnflhrdlaarncml
rddmtvcvadfglskkiysgdyyrqgriakmpvkwiaiesladrvytsksdvwafgvtmw
eiatrgmtpypgvqnhemydyllhghrlkqpedcldelyeimyscwrtdpldrptfsvlr
lqleklleslpdv

    Sequence, based on observed residues (ATOM records):
    >3bprC (C:)
nkledvvidrnllilgkilgegefgsvmegnlkqedgtslkvavktmkieeflseaacmk
dfshpnvirllgvciemsqpmvilpfmkygdlhtyllysrletgpkhiplqtllkfmvdi
algmeylsnrnflhrdlaarncmlrddmtvcvadfglspvkwiaiesladrvytsksdvw
afgvtmweiatrgmtpypgvqnhemydyllhghrlkqpedcldelyeimyscwrtdpldr
ptfsvlrlqleklleslpd

  • Chain 'D':
    Sequence, based on SEQRES records:
    >3bprD (D:)
mgsshhhhhhssglvprgseelqnkledvvidrnllilgkilgegefgsvmegnlkqedg
tslkvavktmkldnssqreieeflseaacmkdfshpnvirllgvciemssqgipkpmvil
pfmkygdlhtyllysrletgpkhiplqtllkfmvdialgmeylsnrnflhrdlaarncml
rddmtvcvadfglskkiysgdyyrqgriakmpvkwiaiesladrvytsksdvwafgvtmw
eiatrgmtpypgvqnhemydyllhghrlkqpedcldelyeimyscwrtdpldrptfsvlr
lqleklleslpdv

    Sequence, based on observed residues (ATOM records):
    >3bprD (D:)
nkledvvidrnllilgkilgegefgsvmegnlkqedgtslkvavktmkieeflseaacmk
dfshpnvirllgvciemsspmvilpfmkygdlhtyllysrletgpkhiplqtllkfmvdi
algmeylsnrnflhrdlaarncmlrddmtvcvadfglspvkwiaiesladrvytsksdvw
afgvtmweiatrgmtpypgvqnhemydyllhghrlkqpedcldelyeimyscwrtdpldr
ptfsvlrlqleklleslpd