PDB entry 3bpl

View 3bpl on RCSB PDB site
Description: Crystal structure of the IL4-IL4R-Common Gamma ternary complex
Class: Cytokine/Cytokine receptor
Keywords: IL4, IL13, receptor, cytokine, B-cell activation, Glycoprotein, Growth factor, Secreted, Immune response, Membrane, Phosphoprotein, Transmembrane, Disease mutation, Host-virus interaction, SCID, Cytokine-receptor COMPLEX, Cytokine-Cytokine receptor COMPLEX
Deposited on 2007-12-18, released 2008-02-05
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 2.93 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: interleukin-4
    Species: Homo sapiens [TaxId:9606]
    Gene: IL4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3bpla_
  • Chain 'B':
    Compound: Interleukin-4 receptor alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: IL4R, 582J2.1, IL4RA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P24394 (4-End)
      • expression tag (0-3)
      • engineered (30)
      • engineered (75)
      • engineered (111)
      • engineered (153)
    Domains in SCOPe 2.08: d3bplb1, d3bplb2, d3bplb3
  • Chain 'C':
    Compound: Cytokine receptor common gamma chain
    Species: Homo sapiens [TaxId:9606]
    Gene: IL2RG
    Database cross-references and differences (RAF-indexed):
    • Uniprot P31785 (0-End)
      • engineered (19)
    Domains in SCOPe 2.08: d3bplc1, d3bplc2
  • Heterogens: NAG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3bplA (A:)
hkcditlqeiiktlnslteqktlcteltvtdifaaskntteketfcraatvlrqfyshhe
kdtrclgataqqfhrhkqlirflkrldrnlwglaglnscpvkeanqstlenflerlktim
rekyskcss

    Sequence, based on observed residues (ATOM records): (download) 
    >3bplA (A:)
cditlqeiiktlnslteqktlcteltvtdifaaskntteketfcraatvlrqfyshhekd
trclgataqqfhrhkqlirflkrldrnlwglaglnscpvkeanqstlenflerlktimre
kyskcs

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3bplB (B:)
adpfkvlqeptcvsdymsistcewkmngptqcstelrllyqlvfllseahtcipenngga
gcvchllmddvvsadqytldlwagqqllwkgsfkpsehvkprapgnltvhtqvsdtlllt
wsnpyppdnylynhltyavniwsendpadfriyqvtylepslriaastlksgisyrarvr
awaqcynttwsewspstkwhnsyre

    Sequence, based on observed residues (ATOM records): (download) 
    >3bplB (B:)
adpfkvlqeptcvsdymsistcewkmngptqcstelrllyqlvfllseahtcipenngga
gcvchllmddvvsadqytldlwagqqllwkgsfkpsehvkprapgnltvhtqvsdtlllt
wsnpyppdnylynhltyavniwsendpadfriyqvtylepslriaastlksgisyrarvr
awaqcynttwsewspstkwhns

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3bplC (C:)
plpevqcfvfnveymnctwqsssepqptnltlhywyknsdndkvqkcshylfseeitsgc
qlqkkeihlyqtfvvqlqdpreprrqatqmlklqnlvipwapenltlhklsesqlelnwn
nrflnhclehlvqyrtdwdhswteqsvdyrhkfslpsvdgqkrytfrvrsrfnplcgsaq
hwsewshpihwgsntsken

    Sequence, based on observed residues (ATOM records): (download) 
    >3bplC (C:)
plpevqcfvfnveymnctwqsssepqptnltlhywyknsdndkvqkcshylfseeitsgc
qlqkkeihlyqtfvvqlqdpreprrqatqmlklqnlvipwapenltlhklsesqlelnwn
nrflnhclehlvqyrtdwdhswteqsvdyrhkfslpsvdgqkrytfrvrsrfnplcgsaq
hwsewshpihwgsn