PDB entry 3bpf

View 3bpf on RCSB PDB site
Description: Crystal Structure of Falcipain-2 with Its inhibitor, E64
Class: hydrolase
Keywords: falcipain, malaria, cysteine protease, Hydrolase, Thiol protease
Deposited on 2007-12-18, released 2008-12-30
The last revision prior to the SCOPe 2.02 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: 0.278
AEROSPACI score: 0.16 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cysteine protease falcipain-2
    Species: Plasmodium falciparum [TaxId:5833]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9NBD4 (0-240)
      • see remark 999 (170)
    Domains in SCOPe 2.02: d3bpfa_
  • Chain 'B':
    Compound: Cysteine protease falcipain-2
    Species: Plasmodium falciparum [TaxId:5833]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9NBD4 (0-End)
      • see remark 999 (170)
    Domains in SCOPe 2.02: d3bpfb_
  • Chain 'C':
    Compound: Cysteine protease falcipain-2
    Species: Plasmodium falciparum [TaxId:5833]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9NBD4 (Start-240)
      • see remark 999 (170)
    Domains in SCOPe 2.02: d3bpfc_
  • Chain 'D':
    Compound: Cysteine protease falcipain-2
    Species: Plasmodium falciparum [TaxId:5833]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9NBD4 (Start-240)
      • see remark 999 (170)
    Domains in SCOPe 2.02: d3bpfd_
  • Heterogens: E64, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3bpfA (A:)
qmnyeevikkyrgeenfdhaaydwrlhsgvtpvkdqkncgscwafssigsvesqyairkn
klitlseqelvdcsfknygcngglinnafedmielggicpdgdypyvsdapnlcnidrct
ekygiknylsvpdnklkealrflgpisisvavsddfafykegifdgecgdqlnhavmlvg
fgmkeivnpltkkgekhyyyiiknswgqqwgergfinietdesglmrkcglgtdafipli
e

    Sequence, based on observed residues (ATOM records): (download) 
    >3bpfA (A:)
qmnyeevikkyrgeenfdhaaydwrlhsgvtpvkdqkncgscwafssigsvesqyairkn
klitlseqelvdcsfknygcngglinnafedmielggicpdgdypyvsdapnlcnidrct
ekygiknylsvpdnklkealrflgpisisvavsddfafykegifdgecgdqlnhavmlvg
fgmkeivngekhyyyiiknswgqqwgergfinietdesglmrkcglgtdafiplie

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3bpfB (B:)
qmnyeevikkyrgeenfdhaaydwrlhsgvtpvkdqkncgscwafssigsvesqyairkn
klitlseqelvdcsfknygcngglinnafedmielggicpdgdypyvsdapnlcnidrct
ekygiknylsvpdnklkealrflgpisisvavsddfafykegifdgecgdqlnhavmlvg
fgmkeivnpltkkgekhyyyiiknswgqqwgergfinietdesglmrkcglgtdafipli
e

    Sequence, based on observed residues (ATOM records): (download) 
    >3bpfB (B:)
qmnyeevikkyrgeenfdhaaydwrlhsgvtpvkdqkncgscwafssigsvesqyairkn
klitlseqelvdcsfknygcngglinnafedmielggicpdgdypyvsdapnlcnidrct
ekygiknylsvpdnklkealrflgpisisvavsddfafykegifdgecgdqlnhavmlvg
fgmkeivnpltkkgekhyyyiiknswgqqwgergfinietdesglmrkcglgtdafipli

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3bpfC (C:)
qmnyeevikkyrgeenfdhaaydwrlhsgvtpvkdqkncgscwafssigsvesqyairkn
klitlseqelvdcsfknygcngglinnafedmielggicpdgdypyvsdapnlcnidrct
ekygiknylsvpdnklkealrflgpisisvavsddfafykegifdgecgdqlnhavmlvg
fgmkeivnpltkkgekhyyyiiknswgqqwgergfinietdesglmrkcglgtdafipli
e

    Sequence, based on observed residues (ATOM records): (download) 
    >3bpfC (C:)
mnyeevikkydhaaydwrlhsgvtpvkdqkncgscwafssigsvesqyairknklitlse
qelvdcsfknygcngglinnafedmielggicpdgdypyvsdapnlcnidrctekygikn
ylsvpdnklkealrflgpisisvavsddfafykegifdgecgdqlnhavmlvgfgmkeiv
npltkkgekhyyyiiknswgqqwgergfinietdesglmrkcglgtdafiplie

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3bpfD (D:)
qmnyeevikkyrgeenfdhaaydwrlhsgvtpvkdqkncgscwafssigsvesqyairkn
klitlseqelvdcsfknygcngglinnafedmielggicpdgdypyvsdapnlcnidrct
ekygiknylsvpdnklkealrflgpisisvavsddfafykegifdgecgdqlnhavmlvg
fgmkeivnpltkkgekhyyyiiknswgqqwgergfinietdesglmrkcglgtdafipli
e

    Sequence, based on observed residues (ATOM records): (download) 
    >3bpfD (D:)
mnyeevikkyaaydwrlhsgvtpvkdqkncgscwafssigsvesqyairknklitlseqe
lvdcsfknygcngglinnafedmielggicpdgdypyvsdapnlcnidrctekygiknyl
svpdnklkealrflgpisisvavsddfafykegifdgecgdqlnhavmlvgfyyiiknsw
gqqwgergfinietdesglmrkcglgtdafiplie