PDB entry 3bn9

View 3bn9 on RCSB PDB site
Description: Crystal Structure of MT-SP1 in complex with Fab Inhibitor E2
Class: hydrolase
Keywords: Antibody-Protease Complex, Protein-Protein Complex, Enzyme-Inhibitor Complex, Disease mutation, Glycoprotein, Hydrolase, Membrane, Polymorphism, Serine protease, Signal-anchor, Transmembrane
Deposited on 2007-12-13, released 2008-09-09
The last revision prior to the SCOPe 2.03 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.17 Å
R-factor: 0.226
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Membrane-type serine protease 1
    Species: HOMO SAPIENS
    Gene: ST14, PRSS14, SNC19, TADG15
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9Y5Y6 (0-240)
      • engineered (116)
    Domains in SCOPe 2.03: d3bn9a_
  • Chain 'B':
    Compound: Membrane-type serine protease 1
    Species: HOMO SAPIENS
    Gene: ST14, PRSS14, SNC19, TADG15
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9Y5Y6 (0-240)
      • engineered (116)
    Domains in SCOPe 2.03: d3bn9b_
  • Chain 'C':
    Compound: E2 Fab Light Chain
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed):
    • PDB 3BN9 (0-End)
    Domains in SCOPe 2.03: d3bn9c1, d3bn9c2
  • Chain 'D':
    Compound: E2 Fab Heavy Chain
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed):
    • PDB 3BN9 (0-End)
    Domains in SCOPe 2.03: d3bn9d1, d3bn9d2
  • Chain 'E':
    Compound: E2 Fab Light Chain
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed):
    • PDB 3BN9 (0-End)
    Domains in SCOPe 2.03: d3bn9e1, d3bn9e2
  • Chain 'F':
    Compound: E2 Fab Heavy Chain
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed):
    • PDB 3BN9 (0-End)
    Domains in SCOPe 2.03: d3bn9f1, d3bn9f2
  • Heterogens: EDO, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3bn9A (A:)
    vvggtdadegewpwqvslhalgqghicgaslispnwlvsaahcyiddrgfrysdptqwta
    flglhdqsqrsapgvqerrlkriishpffndftfdydiallelekpaeyssmvrpislpd
    ashvfpagkaiwvtgwghtqyggtgalilqkgeirvinqttcenllpqqitprmmcvgfl
    sggvdscqgdsggplssveadgrifqagvvswgdgcaqrnkpgvytrlplfrdwikentg
    v
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3bn9B (B:)
    vvggtdadegewpwqvslhalgqghicgaslispnwlvsaahcyiddrgfrysdptqwta
    flglhdqsqrsapgvqerrlkriishpffndftfdydiallelekpaeyssmvrpislpd
    ashvfpagkaiwvtgwghtqyggtgalilqkgeirvinqttcenllpqqitprmmcvgfl
    sggvdscqgdsggplssveadgrifqagvvswgdgcaqrnkpgvytrlplfrdwikentg
    v
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >3bn9C (C:)
    diqmtqspsslsasvgdrvtitcrasqgissylawyqqkpgkapklliyaasslqsgvps
    rfsgsgsgtdftltisslqpedfavyycqqhgnlpytfgdgtkveikrtvaapsvfifpp
    sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
    lskadyekhkvyacevthqglsspvtksfnrgec
    

    Sequence, based on observed residues (ATOM records): (download)
    >3bn9C (C:)
    diqmtqspsslsasvgdrvtitcrasqgissylawyqqkpgkapklliyaasslqsgvps
    rfsgsgsgtdftltisslqpedfavyycqqhgnlpytfgdgtkveikrtvaapsvfifpp
    sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
    lskadyekhkvyacevthqglsspvtksfn
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >3bn9D (D:)
    qvqlvqsggglvkpggslrlscaasgftfssyamswvrqapgkglewvsaisgsggstyy
    adsvkgrftisrdnskntlylqmsslraedtavyycarpyltypqrrgpqnvspfdnwgq
    gtmvtvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvht
    fpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscaaahhhhhh
    gaaeqkliseedlngaa
    

    Sequence, based on observed residues (ATOM records): (download)
    >3bn9D (D:)
    qvqlvqsggglvkpggslrlscaasgftfssyamswvrqapgkglewvsaisgsggstyy
    adsvkgrftisrdnskntlylqmsslraedtavyycarpyltypqrrgpqnvspfdnwgq
    gtmvtvssastkgpsvfplaplgclvkdyfpepvtvswnsgaltsgvhtfpavlqssgly
    slssvvtvptyicnvnhkpsntkvdkkvepk
    

  • Chain 'E':
    Sequence, based on SEQRES records: (download)
    >3bn9E (E:)
    diqmtqspsslsasvgdrvtitcrasqgissylawyqqkpgkapklliyaasslqsgvps
    rfsgsgsgtdftltisslqpedfavyycqqhgnlpytfgdgtkveikrtvaapsvfifpp
    sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
    lskadyekhkvyacevthqglsspvtksfnrgec
    

    Sequence, based on observed residues (ATOM records): (download)
    >3bn9E (E:)
    diqmtqspsslsasvgdrvtitcrasqgissylawyqqkpgkapklliyaasslqsgvps
    rfsgsgsgtdftltisslqpedfavyycqqhgnlpytfgdgtkveikrtvaapsvfifpp
    sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
    lskadyekhkvyacevthqglsspvtksfnr
    

  • Chain 'F':
    Sequence, based on SEQRES records: (download)
    >3bn9F (F:)
    qvqlvqsggglvkpggslrlscaasgftfssyamswvrqapgkglewvsaisgsggstyy
    adsvkgrftisrdnskntlylqmsslraedtavyycarpyltypqrrgpqnvspfdnwgq
    gtmvtvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvht
    fpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscaaahhhhhh
    gaaeqkliseedlngaa
    

    Sequence, based on observed residues (ATOM records): (download)
    >3bn9F (F:)
    qvqlvqsggglvkpggslrlscaasgftfssyamswvrqapgkglewvsaisgsggstyy
    adsvkgrftisrdnskntlylqmsslraedtavyycarpyltypqrrgpqnvspfdnwgq
    gtmvtvssastkgpsvfplapsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavl
    qssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepk