PDB entry 3bgl

View 3bgl on RCSB PDB site
Description: hepatoselectivity of statins: design and synthesis of 4-sulfamoyl pyrroles as hmg-coa reductase inhibitors
Deposited on 2007-11-26, released 2008-01-29
The last revision was dated 2021-10-20, with a file datestamp of 2021-10-15.
Experiment type: XRAY
Resolution: 2.23 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 3-hydroxy-3-methylglutaryl-coenzyme A reductase
    Species: Homo sapiens [TaxId:9606]
    Gene: HMGCR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04035 (6-440)
      • expression tag (0-5)
      • engineered mutation (50)
  • Chain 'B':
    Compound: 3-hydroxy-3-methylglutaryl-coenzyme A reductase
    Species: Homo sapiens [TaxId:9606]
    Gene: HMGCR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04035 (6-440)
      • expression tag (0-5)
      • engineered mutation (50)
  • Chain 'C':
    Compound: 3-hydroxy-3-methylglutaryl-coenzyme A reductase
    Species: Homo sapiens [TaxId:9606]
    Gene: HMGCR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04035 (6-440)
      • expression tag (0-5)
      • engineered mutation (50)
  • Chain 'D':
    Compound: 3-hydroxy-3-methylglutaryl-coenzyme A reductase
    Species: Homo sapiens [TaxId:9606]
    Gene: HMGCR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04035 (6-440)
      • expression tag (0-5)
      • engineered mutation (50)
  • Heterogens: RID, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >3bglA (A:)
hhhhhheprpneeclqilgnaekgakflsdaeiiqlvnakhipaykletliethergvsi
rrqllskklsepsslqylpyrdynyslvmgaccenvigympipvgvagplcldekefqvp
mattegclvastnrgcraiglgggassrvladgmtrgpvvrlpracdsaevkawletseg
favikeafdstsrfarlqklhtsiagrnlyirfqsrsgdamgmnmiskgtekalsklhey
fpemqilavsgnyctdkkpaainwiegrgksvvceavipakvvrevlkttteamievnin
knlvgsamagsiggynahaanivtaiyiacgqdaaqnvgssncitlmeasgptnedlyis
ctmpsieigtvgggtnllpqqaclqmlgvqgackdnpgenarqlarivcgtvmagelslm
aalaaghlvkshmihnrskin

    Sequence, based on observed residues (ATOM records):
    >3bglA (A:)
eprpneeclqilgnaekgakflsdaeiiqlvnakhipaykletliethergvsirrqlls
kklsepsslqylpyrdynyslvmgaccenvigympipvgvagplcldekefqvpmatteg
clvastnrgcraiglgggassrvladgmtrgpvvrlpracdsaevkawletsegfavike
afdstsrfarlqklhtsiagrnlyirfqsrsgdamgmnmiskgtekalsklheyfpemqi
lavsgnyctdkkpaainwiegrgksvvceavipakvvrevlkttteamievninknlvgs
amagsiggynahaanivtaiyiacgqdaaqnvgssncitlmeasgptnedlyisctmpsi
eigtvgggtnllpqqaclqmlgvqgackdnpgenarqlarivcgtvmagelslmaalaag
h

  • Chain 'B':
    Sequence, based on SEQRES records:
    >3bglB (B:)
hhhhhheprpneeclqilgnaekgakflsdaeiiqlvnakhipaykletliethergvsi
rrqllskklsepsslqylpyrdynyslvmgaccenvigympipvgvagplcldekefqvp
mattegclvastnrgcraiglgggassrvladgmtrgpvvrlpracdsaevkawletseg
favikeafdstsrfarlqklhtsiagrnlyirfqsrsgdamgmnmiskgtekalsklhey
fpemqilavsgnyctdkkpaainwiegrgksvvceavipakvvrevlkttteamievnin
knlvgsamagsiggynahaanivtaiyiacgqdaaqnvgssncitlmeasgptnedlyis
ctmpsieigtvgggtnllpqqaclqmlgvqgackdnpgenarqlarivcgtvmagelslm
aalaaghlvkshmihnrskin

    Sequence, based on observed residues (ATOM records):
    >3bglB (B:)
eprpneeclqilgnaekgakflsdaeiiqlvnakhipaykletliethergvsirrqlls
kklsepsslqylpyrdynyslvmgaccenvigympipvgvagplcldekefqvpmatteg
clvastnrgcraiglgggassrvladgmtrgpvvrlpracdsaevkawletsegfavike
afdstsrfarlqklhtsiagrnlyirfqsrsgdamgmnmiskgtekalsklheyfpemqi
lavsgnyctdkkpaainwiegrgksvvceavipakvvrevlkttteamievninknlvgs
amagsiggynahaanivtaiyiacgqdaaqnvgssncitlmeasgptnedlyisctmpsi
eigtvgggtnllpqqaclqmlgvqgackdnpgenarqlarivcgtvmagelslmaalaag
h

  • Chain 'C':
    Sequence, based on SEQRES records:
    >3bglC (C:)
hhhhhheprpneeclqilgnaekgakflsdaeiiqlvnakhipaykletliethergvsi
rrqllskklsepsslqylpyrdynyslvmgaccenvigympipvgvagplcldekefqvp
mattegclvastnrgcraiglgggassrvladgmtrgpvvrlpracdsaevkawletseg
favikeafdstsrfarlqklhtsiagrnlyirfqsrsgdamgmnmiskgtekalsklhey
fpemqilavsgnyctdkkpaainwiegrgksvvceavipakvvrevlkttteamievnin
knlvgsamagsiggynahaanivtaiyiacgqdaaqnvgssncitlmeasgptnedlyis
ctmpsieigtvgggtnllpqqaclqmlgvqgackdnpgenarqlarivcgtvmagelslm
aalaaghlvkshmihnrskin

    Sequence, based on observed residues (ATOM records):
    >3bglC (C:)
pneeclqilgngakflsdaeiiqlvnakhipaykletliethergvsirrqllskklsep
sslqylpyrdynyslvmgaccenvigympipvgvagplcldekefqvpmattegclvast
nrgcraiglgggassrvladgmtrgpvvrlpracdsaevkawletsegfavikeafdsts
rfarlqklhtsiagrnlyirfqsrsgdamgmnmiskgtekalsklheyfpemqilavsgn
yctdkkpaainwiegrgksvvceavipakvvrevlkttteamievninknlvgsamagsi
ggynahaanivtaiyiacgqdaaqnvgssncitlmeasgptnedlyisctmpsieigtvg
ggtnllpqqaclqmlgvqgackdnpgenarqlarivcgtvmagelslmaalaag

  • Chain 'D':
    Sequence, based on SEQRES records:
    >3bglD (D:)
hhhhhheprpneeclqilgnaekgakflsdaeiiqlvnakhipaykletliethergvsi
rrqllskklsepsslqylpyrdynyslvmgaccenvigympipvgvagplcldekefqvp
mattegclvastnrgcraiglgggassrvladgmtrgpvvrlpracdsaevkawletseg
favikeafdstsrfarlqklhtsiagrnlyirfqsrsgdamgmnmiskgtekalsklhey
fpemqilavsgnyctdkkpaainwiegrgksvvceavipakvvrevlkttteamievnin
knlvgsamagsiggynahaanivtaiyiacgqdaaqnvgssncitlmeasgptnedlyis
ctmpsieigtvgggtnllpqqaclqmlgvqgackdnpgenarqlarivcgtvmagelslm
aalaaghlvkshmihnrskin

    Sequence, based on observed residues (ATOM records):
    >3bglD (D:)
prpneeclgakflsdaeiiqlvnakhipaykletliethergvsirrqllskklsepssl
qylpyrdynyslvmgaccenvigympipvgvagplcldekefqvpmattegclvastnrg
craiglgggassrvladgmtrgpvvrlpracdsaevkawletsegfavikeafdstsrfa
rlqklhtsiagrnlyirfqsrsgdamgmnmiskgtekalsklheyfpemqilavsgnyct
dkkpaainwiegrgksvvceavipakvvrevlkttteamievninknlvgsamagsiggy
nahaanivtaiyiacgqdaaqnvgssncitlmeasgptnedlyisctmpsieigtvgggt
nllpqqaclqmlgvqgackdnpgenarqlarivcgtvmagelslmaalaa