PDB entry 3be2

View 3be2 on RCSB PDB site
Description: Crystal structure of the VEGFR2 kinase domain in complex with a benzamide inhibitor
Class: transferase
Keywords: angiogenesis, receptor tyrosine kinase, ATP-binding, Developmental protein, Differentiation, Glycoprotein, Host-virus interaction, Immunoglobulin domain, Membrane, Nucleotide-binding, Phosphorylation, Polymorphism, Transferase, Transmembrane, Tyrosine-protein kinase
Deposited on 2007-11-16, released 2008-04-08
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-07-26, with a file datestamp of 2017-07-21.
Experiment type: XRAY
Resolution: 1.75 Å
R-factor: N/A
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Vascular endothelial growth factor receptor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: KDR, FLK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P35968 (0-124)
      • engineered (2)
      • engineered (101)
      • engineered (125)
      • expression tag (307-311)
    • Uniprot P35968 (125-306)
    Domains in SCOPe 2.08: d3be2a1, d3be2a2
  • Heterogens: RAJ, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3be2A (A:)
ehaerlpydaskwefprdrlklgkplgrgafgqvieadafgidktatcrtvavkmlkega
thsehralmselkilihighhlnvvnllgactkpggplmvitefckfgnlstylrskrne
fvpykvapedlykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvki
cdfglardiykdpdyvrkgdarlplkwmapetifdrvytiqsdvwsfgvllweifslgas
pypgvkideefcrrlkegtrmrapdyttpemyqtmldcwhgepsqrptfselvehlgnll
qanaqqdrhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3be2A (A:)
ehaerlpydaskwefprdrlklgkplgrgafgqvieadafgidtcrtvavkmlkegaths
ehralmselkilihighhlnvvnllgactkpggplmvitefckfgnlstylrskrnefvp
ykvapedlykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvkicdf
gplkwmapetifdrvytiqsdvwsfgvllweifslgaspypgvkideefcrrlkegtrmr
apdyttpemyqtmldcwhgepsqrptfselvehlgnllqanaqqdrhhhh