PDB entry 3b8r

View 3b8r on RCSB PDB site
Description: Crystal structure of the VEGFR2 kinase domain in complex with a naphthamide inhibitor
Class: transferase
Keywords: receptor tyrosine kinase, angiogenesis, ATP-binding, Developmental protein, Differentiation, Glycoprotein, Host-virus interaction, Immunoglobulin domain, Membrane, Nucleotide-binding, Phosphorylation, Polymorphism, Transferase, Transmembrane, Tyrosine-protein kinase
Deposited on 2007-11-01, released 2008-04-01
The last revision prior to the SCOPe 2.04 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: 0.204
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Vascular endothelial growth factor receptor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: KDR, FLK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P35968 (Start-124)
      • engineered (101)
      • engineered (125)
      • expression tag (307-313)
    • Uniprot P35968 (125-306)
    Domains in SCOPe 2.04: d3b8ra_
  • Chain 'B':
    Compound: Vascular endothelial growth factor receptor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: KDR, FLK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P35968 (Start-124)
      • engineered (101)
    • Uniprot P35968
    Domains in SCOPe 2.04: d3b8rb_
  • Heterogens: EDO, 887, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3b8rA (A:)
ehaerlpydaskwefprdrlklgkplgrgafgqvieadafgidktatcrtvavkmlkega
thsehralmselkilihighhlnvvnllgactkpggplmvitefckfgnlstylrskrne
fvpykvapedlykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvki
cdfglardiykdpdyvrkgdarlplkwmapetifdrvytiqsdvwsfgvllweifslgas
pypgvkideefcrrlkegtrmrapdyttpemyqtmldcwhgepsqrptfselvehlgnll
qanaqqdrhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3b8rA (A:)
erlpydaskwefprdrlklgkplgqvieadafgidktatcrtvavkmlkegathsehral
mselkilihighhlnvvnllgactkpggplmvitefckfgnlstylrskrnefvpykvap
edlykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvkicdfgllpl
kwmapetifdrvytiqsdvwsfgvllweifslgaspypgvkideefcrrlkegtrmrapd
yttpemyqtmldcwhgepsqrptfselvehlgnllqanaqqdrhhhhhh

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3b8rB (B:)
ehaerlpydaskwefprdrlklgkplgrgafgqvieadafgidktatcrtvavkmlkega
thsehralmselkilihighhlnvvnllgactkpggplmvitefckfgnlstylrskrne
fvpykvapedlykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvki
cdfglardiykdpdyvrkgdarlplkwmapetifdrvytiqsdvwsfgvllweifslgas
pypgvkideefcrrlkegtrmrapdyttpemyqtmldcwhgepsqrptfselvehlgnll
qanaqqdrhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3b8rB (B:)
pydaskwefprdrlklgkplgrgqvieadafgidktatcrtvavkmlathsehralmsel
kilihighhlnvvnllgactkpggplmvitefckfgnlstylrskrnefvpykykdfltl
ehlicysfqvakgmeflasrkcihrdlaarnillseknvvkicdfgllplkwmapetifd
rvytiqsdvwsfgvllweifslgaspypgvkideefcrrlkegtrmrapdyttpemyqtm
ldcwhgepsqrptfselvehlgnllqa