PDB entry 3b6o

View 3b6o on RCSB PDB site
Description: Structure of TREX1 in complex with a nucleotide and an inhibitor ion (lithium)
Class: hydrolase
Keywords: TREX1, DEDD, exonuclease, DnaQ, lithium, catalysis, inhibition, deoxy-thimidine monophosphate (dTMP), DNA damage, DNA repair, Hydrolase, Magnesium, Nucleus, Phosphorylation
Deposited on 2007-10-29, released 2008-09-23
The last revision prior to the SCOP 1.75 freeze date was dated 2008-12-02, with a file datestamp of 2008-11-28.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.215
AEROSPACI score: 0.51 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Three prime repair exonuclease 1
    Species: Mus musculus [TaxId:10090]
    Gene: Trex1
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d3b6oa1
  • Chain 'B':
    Compound: Three prime repair exonuclease 1
    Species: Mus musculus [TaxId:10090]
    Gene: Trex1
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d3b6ob1
  • Chain 'C':
    Compound: Three prime repair exonuclease 1
    Species: Mus musculus [TaxId:10090]
    Gene: Trex1
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d3b6oc1
  • Chain 'D':
    Compound: Three prime repair exonuclease 1
    Species: Mus musculus [TaxId:10090]
    Gene: Trex1
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d3b6od1
  • Heterogens: LI, TMP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3b6oA (A:)
mkhhhhhhpmghmqtlifldleatglpssrpevtelcllavhrralentsisqghpppvp
rpprvvdklslciapgkacspgaseitglskaelevqgrqrfddnlaillraflqrqpqp
cclvahngdrydfpllqtelarlstpspldgtfcvdsiaalkaleqasspsgngsrksys
lgsiytrlywqaptdshtaegdvltllsicqwkpqallqwvdeharpfstvkpmygtpat
tgttnlr

    Sequence, based on observed residues (ATOM records): (download) 
    >3b6oA (A:)
ghmqtlifldleatglpssrpevtelcllavhrralentsisqghpppvprpprvvdkls
lciapgkacspgaseitglskaelevqgrqrfddnlaillraflqrqpqpcclvahngdr
ydfpllqtelarlstpspldgtfcvdsiaalkaleqaksyslgsiytrlywqaptdshta
egdvltllsicqwkpqallqwvdeharpfstvkpmyg

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3b6oB (B:)
mkhhhhhhpmghmqtlifldleatglpssrpevtelcllavhrralentsisqghpppvp
rpprvvdklslciapgkacspgaseitglskaelevqgrqrfddnlaillraflqrqpqp
cclvahngdrydfpllqtelarlstpspldgtfcvdsiaalkaleqasspsgngsrksys
lgsiytrlywqaptdshtaegdvltllsicqwkpqallqwvdeharpfstvkpmygtpat
tgttnlr

    Sequence, based on observed residues (ATOM records): (download) 
    >3b6oB (B:)
ghmqtlifldleatglpssrpevtelcllavhrralentsisqghpppvprpprvvdkls
lciapgkacspgaseitglskaelevqgrqrfddnlaillraflqrqpqpcclvahngdr
ydfpllqtelarlstpspldgtfcvdsiaalkaleqaksyslgsiytrlywqaptdshta
egdvltllsicqwkpqallqwvdeharpfstvkpmyg

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3b6oC (C:)
mkhhhhhhpmghmqtlifldleatglpssrpevtelcllavhrralentsisqghpppvp
rpprvvdklslciapgkacspgaseitglskaelevqgrqrfddnlaillraflqrqpqp
cclvahngdrydfpllqtelarlstpspldgtfcvdsiaalkaleqasspsgngsrksys
lgsiytrlywqaptdshtaegdvltllsicqwkpqallqwvdeharpfstvkpmygtpat
tgttnlr

    Sequence, based on observed residues (ATOM records): (download) 
    >3b6oC (C:)
ghmqtlifldleatglpssrpevtelcllavhrralentsisqghpppvprpprvvdkls
lciapgkacspgaseitglskaelevqgrqrfddnlaillraflqrqpqpcclvahngdr
ydfpllqtelarlstpspldgtfcvdsiaalkaleqaksyslgsiytrlywqaptdshta
egdvltllsicqwkpqallqwvdeharpfstvkpmyg

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3b6oD (D:)
mkhhhhhhpmghmqtlifldleatglpssrpevtelcllavhrralentsisqghpppvp
rpprvvdklslciapgkacspgaseitglskaelevqgrqrfddnlaillraflqrqpqp
cclvahngdrydfpllqtelarlstpspldgtfcvdsiaalkaleqasspsgngsrksys
lgsiytrlywqaptdshtaegdvltllsicqwkpqallqwvdeharpfstvkpmygtpat
tgttnlr

    Sequence, based on observed residues (ATOM records): (download) 
    >3b6oD (D:)
ghmqtlifldleatglpssrpevtelcllavhrralentsisqghpppvprpprvvdkls
lciapgkacspgaseitglskaelevqgrqrfddnlaillraflqrqpqpcclvahngdr
ydfpllqtelarlstpspldgtfcvdsiaalkaleqaksyslgsiytrlywqaptdshta
egdvltllsicqwkpqallqwvdeharpfstvkpmyg