PDB entry 3b2v
View 3b2v on RCSB PDB site
Description: Crystal structure of the extracellular region of the epidermal growth factor receptor in complex with the Fab fragment of IMC-11F8
Class: immune system/transferase
Keywords: CELL SURFACE RECEPTOR; GLYCOPROTEIN; ANTIGEN:ANTIBODY COMPLEX; FAB FRAGMENT; ANTITUMOR; DRUG, Anti-oncogene, ATP-binding, Cell cycle, Disease mutation, Kinase, Membrane, Nucleotide-binding, Phosphoprotein, Secreted, Transferase, Transmembrane, Tyrosine-protein kinase, IMMUNE SYSTEM-TRANSFERASE COMPLEX
Deposited on
2007-10-19, released
2008-02-19
The last revision prior to the SCOPe 2.08 freeze date was dated
2020-07-29, with a file datestamp of
2020-07-04.
Experiment type: XRAY
Resolution: 3.3 Å
R-factor: N/A
AEROSPACI score: 0.05
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Epidermal growth factor receptor
Species: Homo sapiens [TaxId:9606]
Gene: EGFR, ERBB1
Database cross-references and differences (RAF-indexed):
- Chain 'H':
Compound: IMC-11F8 FAB Heavy chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d3b2vh1, d3b2vh2, d3b2vh3 - Chain 'L':
Compound: IMC-11F8 FAB Light chain
Species: Homo sapiens [TaxId:9606]
Gene: EGFR
Database cross-references and differences (RAF-indexed):
- Heterogens: NAG
PDB Chain Sequences:
- Chain 'A':
No sequence available.
- Chain 'H':
Sequence, based on SEQRES records: (download)
>3b2vH (H:)
qvqlqesgpglvkpsqtlsltctvsggsissgdyywswirqppgkglewigyiyysgstd
ynpslksrvtmsvdtsknqfslkvnsvtaadtavyycarvsifgvgtfdywgqgtlvtvs
sastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqs
sglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepks
Sequence, based on observed residues (ATOM records): (download)
>3b2vH (H:)
qvqlqesgpglvkpsqtlsltctvsggsissgdyywswirqppgkglewigyiyysgstd
ynpslksrvtmsvdtsknqfslkvnsvtaadtavyycarvsifgvgtfdywgqgtlvtvs
sastkgpsvfplapssgtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglys
lssvvtvpssslgtqtyicnvnhkpsntkvdkkvepk
- Chain 'L':
No sequence available.