PDB entry 3asx

View 3asx on RCSB PDB site
Description: Human Squalene synthase in complex with 1-{4-[{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]phenyl}(2,2-dimethylpropyl)amino]-4-oxobutanoyl}piperidine-3-carboxylic acid
Class: transferase/transferase inhibitor
Keywords: isoprene biosynthesis, lipid synthesis, multifunctional enzyme, oxidoreductase, steroid biosynthesis, sterol biosynthesis, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2010-12-22, released 2011-12-21
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-10-11, with a file datestamp of 2017-10-06.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Squalene synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: FDFT1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3asxa_
  • Heterogens: PO4, D99, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3asxA (A:)
mdqdslssslktcykylnqtsrsfaaviqaldgemrnavcifylvlraldtleddmtisv
ekkvpllhnfhsflyqpdwrfmeskekdrqvledfptislefrnlaekyqtviadicrrm
gigmaefldkhvtseqewdkychyvaglvgiglsrlfsasefedplvgedteransmglf
lqktniirdyledqqggrefwpqevwsryvkklgdfakpenidlavqclnelitnalhhi
pdvitylsrlrnqsvfnfcaipqvmaiatlaacynnqqvfkgavkirkgqavtlmmdatn
mpavkaiiyqymeeiyhripdsdpsssktrqiistirtqn

    Sequence, based on observed residues (ATOM records): (download) 
    >3asxA (A:)
lssslktcykylnqtsrsfaaviqaldgemrnavcifylvlraldtleddmtisvekkvp
llhnfhsflyqpdwrfmeskekdrqvledfptislefrnlaekyqtviadicrrmgigma
efldkhvtseqewdkychyvaglvgiglsrlfsasefedplvgedteransmglflqktn
iirdyledqqggrefwpqevwsryvkklgdfakpenidlavqclnelitnalhhipdvit
ylsrlrnqsvfnfcaipqvmaiatlaacynnqqvfkgavkirkgqavtlmmdatnmpavk
aiiyqymeeiyhripdsdpsssktrqiistirtqn