PDB entry 3ara

View 3ara on RCSB PDB site
Description: Discovery of Novel Uracil Derivatives as Potent Human dUTPase Inhibitors
Class: Hydrolase/Hydrolase inhibitor
Keywords: Hydrolase, Magnesium Binding, Hydrolase-Hydrolase inhibitor complex
Deposited on 2010-11-25, released 2010-12-08
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-10-11, with a file datestamp of 2017-10-06.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: N/A
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: deoxyuridine 5'-triphosphate nucleotidohydrolase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3araa_
  • Chain 'B':
    Compound: deoxyuridine 5'-triphosphate nucleotidohydrolase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3arab_
  • Chain 'C':
    Compound: deoxyuridine 5'-triphosphate nucleotidohydrolase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3arac_
  • Heterogens: MKH, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3araA (A:)
    mpcseetpaispskrarpaevggmqlrfarlsehataptrgsaraagydlysaydytipp
    mekavvktdiqialpsgcygrvaprsglaakhfidvgagvidedyrgnvgvvlfnfgkek
    fevkkgdriaqlicerifypeieevqalddtergsggfgstgkn
    

    Sequence, based on observed residues (ATOM records): (download)
    >3araA (A:)
    mqlrfarlsehataptrgsaraagydlysaydytippmekavvktdiqialpsgcygrva
    prsglaakhfidvgagvidedyrgnvgvvlfnfgkekfevkkgdriaqlicerifypeie
    evqal
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >3araB (B:)
    mpcseetpaispskrarpaevggmqlrfarlsehataptrgsaraagydlysaydytipp
    mekavvktdiqialpsgcygrvaprsglaakhfidvgagvidedyrgnvgvvlfnfgkek
    fevkkgdriaqlicerifypeieevqalddtergsggfgstgkn
    

    Sequence, based on observed residues (ATOM records): (download)
    >3araB (B:)
    mqlrfarlsehataptrgsaraagydlysaydytippmekavvktdiqialpsgcygrva
    prsglaakhfidvgagvidedyrgnvgvvlfnfgkekfevkkgdriaqlicerifypeie
    evqal
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >3araC (C:)
    mpcseetpaispskrarpaevggmqlrfarlsehataptrgsaraagydlysaydytipp
    mekavvktdiqialpsgcygrvaprsglaakhfidvgagvidedyrgnvgvvlfnfgkek
    fevkkgdriaqlicerifypeieevqalddtergsggfgstgkn
    

    Sequence, based on observed residues (ATOM records): (download)
    >3araC (C:)
    mqlrfarlsehataptrgsaraagydlysaydytippmekavvktdiqialpsgcygrva
    prsglaakhfidvgagvidedyrgnvgvvlfnfgkekfevkkgdriaqlicerifypeie
    evqal