PDB entry 3aqa

View 3aqa on RCSB PDB site
Description: Crystal structure of the human BRD2 BD1 bromodomain in complex with a BRD2-interactive compound, BIC1
Class: transcription/transcription inhibitor
Keywords: Structural Genomics, RIKEN Structural Genomics/Proteomics Initiative, RSGI, helical bundle, acetyl-lysine recognition, acetylated histone H4, nucleus, TRANSCRIPTION-TRANSCRIPTION INHIBITOR complex
Deposited on 2010-10-27, released 2011-05-18
The last revision prior to the SCOPe 2.04 freeze date was dated 2011-05-18, with a file datestamp of 2011-05-13.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.189
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Bromodomain-containing protein 2
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD2, KIAA9001, RING3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d3aqaa_
  • Chain 'B':
    Compound: Bromodomain-containing protein 2
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD2, KIAA9001, RING3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d3aqab_
  • Chain 'C':
    Compound: Bromodomain-containing protein 2
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD2, KIAA9001, RING3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d3aqac_
  • Heterogens: BYH, MES, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3aqaA (A:)
gssgssgrvtnqlqylhkvvmkalwkhqfawpfrqpvdavklglpdyhkiikqpmdmgti
krrlennyywaasecmqdfntmftncyiynkptddivlmaqtlekiflqkvasmpqeeqe
lvvtipkn

    Sequence, based on observed residues (ATOM records): (download) 
    >3aqaA (A:)
grvtnqlqylhkvvmkalwkhqfawpfrqpvdavklglpdyhkiikqpmdmgtikrrlen
nyywaasecmqdfntmftncyiynkptddivlmaqtlekiflqkvasmpqeeqe

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3aqaB (B:)
gssgssgrvtnqlqylhkvvmkalwkhqfawpfrqpvdavklglpdyhkiikqpmdmgti
krrlennyywaasecmqdfntmftncyiynkptddivlmaqtlekiflqkvasmpqeeqe
lvvtipkn

    Sequence, based on observed residues (ATOM records): (download) 
    >3aqaB (B:)
grvtnqlqylhkvvmkalwkhqfawpfrqpvdavklglpdyhkiikqpmdmgtikrrlen
nyywaasecmqdfntmftncyiynkptddivlmaqtlekiflqkvasmpqee

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3aqaC (C:)
gssgssgrvtnqlqylhkvvmkalwkhqfawpfrqpvdavklglpdyhkiikqpmdmgti
krrlennyywaasecmqdfntmftncyiynkptddivlmaqtlekiflqkvasmpqeeqe
lvvtipkn

    Sequence, based on observed residues (ATOM records): (download) 
    >3aqaC (C:)
tnqlqylhkvvmkalwkhqfawpfrqpvdavklglpdyhkiikqpmdmgtikrrlennyy
waasecmqdfntmftncyiynkptddivlmaqtlekiflqkvasmpq