PDB entry 3aox

View 3aox on RCSB PDB site
Description: X-ray crystal structure of human anaplastic lymphoma kinase in complex with CH5424802
Class: transferase/transferase inhibitor
Keywords: ALK KINASE, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2010-10-08, released 2011-05-25
The last revision prior to the SCOPe 2.08 freeze date was dated 2012-04-04, with a file datestamp of 2012-03-30.
Experiment type: XRAY
Resolution: 1.75 Å
R-factor: 0.17
AEROSPACI score: 0.55 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ALK tyrosine kinase receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ALK
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3aoxa_
  • Heterogens: EMH, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3aoxA (A:)
gmqmelqspeyklsklrtstimtdynpnycfagktssisdlkevprknitlirglghgaf
gevyegqvsgmpndpsplqvavktlpevcseqdeldflmealiiskfnhqnivrcigvsl
qslprfillelmaggdlksflretrprpsqpsslamldllhvardiacgcqyleenhfih
rdiaarnclltcpgpgrvakigdfgmardiyrasyyrkggcamlpvkwmppeafmegift
sktdtwsfgvllweifslgympypsksnqevlefvtsggrmdppkncpgpvyrimtqcwq
hqpedrpnfaiilerieyctqdpdvintalpieygplveeeekv

    Sequence, based on observed residues (ATOM records): (download) 
    >3aoxA (A:)
stimtdynpnycfagktssisdlkevprknitlirglggevyegqvsplqvavktlpevc
seqdeldflmealiiskfnhqnivrcigvslqslprfillelmaggdlksflretrprps
qpsslamldllhvardiacgcqyleenhfihrdiaarnclltcpgpgrvakigdfgmard
iyracamlpvkwmppeafmegiftsktdtwsfgvllweifslgympypsksnqevlefvt
sggrmdppkncpgpvyrimtqcwqhqpedrpnfaiilerieyctqdpdvintalpiey