PDB entry 3ao5

View 3ao5 on RCSB PDB site
Description: fragment-based approach to the design of ligands targeting a novel site on hiv-1 integrase
Deposited on 2010-09-21, released 2011-03-09
The last revision was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: N/A
AEROSPACI score: 0.43 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Pol polyprotein
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q72498
      • engineered mutation (73-74)
      • engineered mutation (77)
      • engineered mutation (81)
      • engineered mutation (135)
  • Chain 'B':
    Compound: Pol polyprotein
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q72498
      • engineered mutation (73-74)
      • engineered mutation (77)
      • engineered mutation (81)
      • engineered mutation (89)
      • engineered mutation (135)
  • Heterogens: BBY, CL, SO4, CD, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >3ao5A (A:)
mhgqvdsspgiwqldcthlegkvilvavhvasgyieaevipaetgqetayfllklagrwp
vktvhtdngsnftgatvraacdwagikqedgipynpqsqgviesmnkelkkiigqvrdqa
ehlktavqmavfihnhkrkggiggysagerivdiiatdiqtke

    Sequence, based on observed residues (ATOM records):
    >3ao5A (A:)
spgiwqldcthlegkvilvavhvasgyieaevipaetgqetayfllklagrwpvktvhtd
ngsnftgatvraacdwagikqesmnkelkkiigqvrdqaehlktavqmavfihnhkrkgg
ysagerivdiiatdi

  • Chain 'B':
    Sequence, based on SEQRES records:
    >3ao5B (B:)
mhgqvdsspgiwqldcthlegkvilvavhvasgyieaevipaetgqetayfllklagrwp
vktvhtdngsnftgatvraacdwagikqedgipynpqsqgviesmnkelkkiigqvrdqa
ehlktavqmavfihnhkrkggiggysagerivdiiatdiqtke

    Sequence, based on observed residues (ATOM records):
    >3ao5B (B:)
spgiwqldcthlegkvilvavhvasgyieaevipaetgqetayfllklagrwpvktvhtd
ngsnftgatvraacdwagikqedgsmnkelkkiigqvrdqaehlktavqmavfihnhkrk
ggiggysagerivdiiatdi