PDB entry 3amv

View 3amv on RCSB PDB site
Description: allosteric inhibition of glycogen phosphorylase a by a potential antidiabetic drug
Class: transferase
Keywords: diabetes, glycogen metabolism, phosphorylase a, inhibition, allosteric site, transferase
Deposited on 1999-02-18, released 1999-02-26
The last revision prior to the SCOPe 2.07 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.189
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: protein (glycogen phosphorylase)
    Species: Oryctolagus cuniculus [TaxId:9986]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00489
      • conflict (608)
    Domains in SCOPe 2.07: d3amva_
  • Heterogens: GLC, PLP, BIN, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3amvA (A:)
srplsdqekrkqisvrglagvenvtelkknfnrhlhftlvkdrnvatprdyyfalahtvr
dhlvgrwirtqqhyyekdpkriyylslefymgrtlqntmvnlalenacdeatyqlgldme
eleeieedaglgngglgrlaacfldsmatlglaaygygiryefgifnqkicggwqmeead
dwlrygnpwekarpeftlpvhfygrvehtsqgakwvdtqvvlampydtpvpgyrnnvvnt
mrlwsakapndfnlkdfnvggyiqavldrnlaenisrvlypndnffegkelrlkqeyfvv
aatlqdiirrfksskfgcrdpvrtnfdafpdkvaiqlndthpslaipelmrvlvdlerld
wdkawevtvktcaytnhtvlpealerwpvhlletllprhlqiiyeinqrflnrvaaafpg
dvdrlrrmslveegavkrinmahlciagshavngvarihseilkktifkdfyelephkfq
nktngitprrwlvlcnpglaeiiaerigeeyisdldqlrkllsyvddeafirdvakvkqe
nklkfaaylereykvhinpnslfdvqvkriheykrqllnclhvitlynrikkepnkfvvp
rtvmiggkaapgyhmakmiiklitaigdvvnhdpvvgdrlrviflenyrvslaekvipaa
dlseqistagteasgtgnmkfmlngaltigtmdganvemaeeageenffifgmrvedvdr
ldqrgynaqeyydripelrqiieqlssgffspkqpdlfkdivnmlmhhdrfkvfadyeey
vkcqervsalyknprewtrmvirniatsgkfssdrtiaqyareiwgvepsrqrlpapdek
ip

    Sequence, based on observed residues (ATOM records): (download) 
    >3amvA (A:)
sdqekrkqisvrglagvenvtelkknfnrhlhftlvkdrnvatprdyyfalahtvrdhlv
grwirtqqhyyekdpkriyylslefymgrtlqntmvnlalenacdeatyqlgldmeelee
ieedaglgngglgrlaacfldsmatlglaaygygiryefgifnqkicggwqmeeaddwlr
ygnpwekarpeftlpvhfygrvehtsqgakwvdtqvvlampydtpvpgyrnnvvntmrlw
sakapnggyiqavldrnlaenisrvlypndnffegkelrlkqeyfvvaatlqdiirrfks
snfdafpdkvaiqlndthpslaipelmrvlvdlerldwdkawevtvktcaytnhtvlpea
lerwpvhlletllprhlqiiyeinqrflnrvaaafpgdvdrlrrmslveegavkrinmah
lciagshavngvarihseilkktifkdfyelephkfqnktngitprrwlvlcnpglaeii
aerigeeyisdldqlrkllsyvddeafirdvakvkqenklkfaaylereykvhinpnslf
dvqvkriheykrqllnclhvitlynrikkepnkfvvprtvmiggkaapgyhmakmiikli
taigdvvnhdpvvgdrlrviflenyrvslaekvipaadlseqistagteasgtgnmkfml
ngaltigtmdganvemaeeageenffifgmrvedvdrldqrgynaqeyydripelrqiie
qlssgffspkqpdlfkdivnmlmhhdrfkvfadyeeyvkcqervsalyknprewtrmvir
niatsgkfssdrtiaqyareiwgvepsrqrlp