PDB entry 3ah8

View 3ah8 on RCSB PDB site
Description: Structure of heterotrimeric G protein Galpha-q beta gamma in complex with an inhibitor YM-254890
Class: signaling protein/inhibitor
Keywords: Heterotrimeric G protein, GTPase, Galpha-q, Gbeta, Ggamma, Inhibitor, YM-254890, SIGNALING PROTEIN, SIGNALING PROTEIN-INHIBITOR complex
Deposited on 2010-04-20, released 2010-07-21
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-08-02, with a file datestamp of 2017-07-28.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: N/A
AEROSPACI score: 0.13 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Guanine nucleotide-binding protein G(i) subunit alpha-1/Guanine nucleotide-binding protein G(q) subunit alpha chimeric protein
    Species: Mus musculus [TaxId:10090]
    Gene: gmhB
    Database cross-references and differences (RAF-indexed):
    • Uniprot P10824 (Start-29)
      • linker (30-31)
    • Uniprot P21279 (32-End)
  • Chain 'B':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
    Species: Bos taurus [TaxId:9913]
    Gene: GNB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3ah8b_
  • Chain 'G':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
    Species: Bos taurus [TaxId:9913]
    Gene: GNG2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3ah8g_
  • Chain 'Y':
    Compound: ym-254890
    Species: Chromobacterium sp. [TaxId:306190]
    Database cross-references and differences (RAF-indexed):
    • PDB 3AH8 (Start-7)
  • Heterogens: GDP

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3ah8B (B:)
mseldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiya
mhwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldni
csiynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttf
tghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngna
fatgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdal
kadragvlaghdnrvsclgvtddgmavatgswdsflkiwn

    Sequence, based on observed residues (ATOM records): (download) 
    >3ah8B (B:)
aeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiyamhwgtdsrll
vsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldnicsiynlktre
gnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttftghtgdvmsl
slapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngnafatgsddatc
rlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdalkadragvlag
hdnrvsclgvtddgmavatgswdsflkiwn

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >3ah8G (G:)
gamdpefmasnntasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltp
vpasenpfrekkffsail

    Sequence, based on observed residues (ATOM records): (download) 
    >3ah8G (G:)
qarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenp

  • Chain 'Y':
    No sequence available.