PDB entry 3ads

View 3ads on RCSB PDB site
Description: Human PPARgamma ligand-binding domain in complex with indomethacin
Class: transcription
Keywords: nuclear receptor, ligand-dependent transcription factor, ligand-binding domain, Activator, Diabetes mellitus, Disease mutation, DNA-binding, Metal-binding, Nucleus, Obesity, Phosphoprotein, Receptor, Transcription, Transcription regulation, Zinc-finger
Deposited on 2010-01-29, released 2010-12-22
The last revision prior to the SCOPe 2.08 freeze date was dated 2010-12-22, with a file datestamp of 2010-12-17.
Experiment type: XRAY
Resolution: 2.25 Å
R-factor: 0.228
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Peroxisome proliferator-activated receptor gamma
    Species: Homo sapiens [TaxId:9606]
    Gene: PPARgamma
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3adsa_
  • Chain 'B':
    Compound: Peroxisome proliferator-activated receptor gamma
    Species: Homo sapiens [TaxId:9606]
    Gene: PPARgamma
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3adsb_
  • Heterogens: IMN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3adsA (A:)
gshmaeissdidqlnpesadlralakhlydsyiksfpltkakarailtgkttdkspfviy
dmnslmmgedkikfkhitplqeqskevairifqgcqfrsveavqeiteyaksipgfvnld
lndqvtllkygvheiiytmlaslmnkdgvlisegqgfmtreflkslrkpfgdfmepkfef
avkfnalelddsdlaifiaviilsgdrpgllnvkpiediqdnllqalelqlklnhpessq
lfakllqkmtdlrqivtehvqllqvikktetdmslhpllqeiykdly

    Sequence, based on observed residues (ATOM records): (download) 
    >3adsA (A:)
qlnpesadlralakhlydsyiksfpltkakarailtgkttdkspfviydmnslmmgedki
kevairifqgcqfrsveavqeiteyaksipgfvnldlndqvtllkygvheiiytmlaslm
nkdgvlisegqgfmtreflkslrkpfgdfmepkfefavkfnalelddsdlaifiaviils
gdrpgllnvkpiediqdnllqalelqlklnhpessqlfakllqkmtdlrqivtehvqllq
vikktetdmslhpllqeiykdl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3adsB (B:)
gshmaeissdidqlnpesadlralakhlydsyiksfpltkakarailtgkttdkspfviy
dmnslmmgedkikfkhitplqeqskevairifqgcqfrsveavqeiteyaksipgfvnld
lndqvtllkygvheiiytmlaslmnkdgvlisegqgfmtreflkslrkpfgdfmepkfef
avkfnalelddsdlaifiaviilsgdrpgllnvkpiediqdnllqalelqlklnhpessq
lfakllqkmtdlrqivtehvqllqvikktetdmslhpllqeiykdly

    Sequence, based on observed residues (ATOM records): (download) 
    >3adsB (B:)
esadlralakhlydsyiksfpltkakarailtgkkspfviydmnslmmgedkikfkkeva
irifqgcqfrsveavqeiteyaksipgfvnldlndqvtllkygvheiiytmlaslmnkdg
vlisegqgfmtreflkslrkpfgdfmepkfefavkfnalelddsdlaifiaviilsgdrp
gllnvkpiediqdnllqalelqlklnhpessqlfakllqkmtdlrqivtehvqllqvikk
tethpllqeiy