PDB entry 3a9e
View 3a9e on RCSB PDB site
Description: Crystal structure of a mixed agonist-bound RAR-alpha and antagonist-bound RXR-alpha heterodimer ligand binding domains
Class: Transcription
Keywords: Transcription, Nucleus, Receptor, Transcription regulation, Structural Genomics, SPINE2-complexes, Structural Proteomics in Europe
Deposited on
2009-10-24, released
2010-10-06
The last revision prior to the SCOPe 2.05 freeze date was dated
2013-10-30, with a file datestamp of
2013-10-25.
Experiment type: XRAY
Resolution: 2.75 Å
R-factor: 0.204
AEROSPACI score: 0.22
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Retinoic acid receptor RXR-alpha
Species: Mus musculus [TaxId:10090]
Gene: RXRA, NR2B1
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.05: d3a9ea_ - Chain 'B':
Compound: retinoic acid receptor alpha
Species: Homo sapiens [TaxId:9606]
Gene: RARA, NR1B1
Database cross-references and differences (RAF-indexed):
- Chain 'I':
Compound: 13-mer (LXXLL motif) from Nuclear receptor coactivator 2
Species: HOMO SAPIENS, synthetic [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Heterogens: 754, REA, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3a9eA (A:)
tssanedmpvekileaelavepktetyveanmglnpsspndpvtnicqaadkqlftlvew
akriphfselplddqvillragwnelliasfshrsiavkdgillatglhvhrnsahsagv
gaifdrvltelvskmrdmqmdktelgclraivlfnpdskglsnpaevealrekvyaslea
yckhkypeqpgrfaklllrlpalrsiglkclehlfffkligdtpidtflmemleaphqat
Sequence, based on observed residues (ATOM records): (download)
>3a9eA (A:)
sanedmpvekileaelavepkspndpvtnicqaadkqlftlvewakriphfselplddqv
illragwnelliasfshrsiavkdgillatglhvhrnsahsagvgaifdrvltelvskmr
dmqmdktelgclraivlfnpdskglsnpaevealrekvyasleayckhkypeqpgrfakl
llrlpalrsiglkclehlfffkligdtpidtflmemle
- Chain 'B':
No sequence available.
- Chain 'I':
No sequence available.