PDB entry 3a6p

View 3a6p on RCSB PDB site
Description: Crystal structure of Exportin-5:RanGTP:pre-miRNA complex
Class: protein transport/nuclear protein/RNA
Keywords: EXPORTIN-5, PRE-MICRORNA, RANGTP, NUCLEAREXPORT, IMPORTIN-BETA FAMILY, Nucleus, Phosphoprotein, Protein transport, RNA-binding, RNA-mediated gene silencing, Transport, tRNA-binding, Cell cycle, Cell division, GTP-binding, Isopeptide bond, Mitosis, Nucleotide-binding, PROTEIN TRANSPORT-NUCLEAR PROTEIN-RNA COMPLEX
Deposited on 2009-09-07, released 2009-12-08
The last revision prior to the SCOPe 2.03 freeze date was dated 2012-04-25, with a file datestamp of 2012-04-20.
Experiment type: XRAY
Resolution: 2.92 Å
R-factor: 0.251
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Exportin-5
    Species: Homo sapiens [TaxId:9606]
    Gene: XPO5, KIAA1291, RANBP21
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: 13-mer peptide
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 3A6P (0-12)
  • Chain 'C':
    Compound: GTP-binding nuclear protein ran
    Species: Canis lupus familiaris [TaxId:9615]
    Gene: RAN
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d3a6pc_
  • Chain 'D':
    Compound: pre-microRNA
  • Chain 'E':
    Compound: pre-microRNA
  • Chain 'F':
    Compound: Exportin-5
    Species: Homo sapiens [TaxId:9606]
    Gene: XPO5, KIAA1291, RANBP21
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: 13-mer peptide
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 3A6P (0-12)
  • Chain 'H':
    Compound: GTP-binding nuclear protein ran
    Species: Canis lupus familiaris [TaxId:9615]
    Gene: RAN
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d3a6ph_
  • Chain 'I':
    Compound: pre-microRNA
  • Chain 'J':
    Compound: pre-microRNA
  • Heterogens: GTP, MG

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >3a6pC (C:)
    maaqgepqvqfklvlvgdggtgkttfvkrhltgefekkyvatlgvevhplvfhtnrgpik
    fnvwdtagqekfgglrdgyyiqaqcaiimfdvtsrvtyknvpnwhrdlvrvcenipivlc
    gnkvdikdrkvkaksivfhrkknlqyydisaksnynfekpflwlarkligdpnlefvamp
    alappevvmdpalaaqyehdlevaqttalpdedddl
    

    Sequence, based on observed residues (ATOM records): (download)
    >3a6pC (C:)
    pqvqfklvlvgdggtgkttfvkrhltgefekkyvatlgvevhplvfhtnrgpikfnvwdt
    agqekfgglrdgyyiqaqcaiimfdvtsrvtyknvpnwhrdlvrvcenipivlcgnkvdi
    kdrkvkaksivfhrkknlqyydisaksnynfekpflwlarkligdpnlef
    

  • Chain 'D':
    No sequence available.

  • Chain 'E':
    No sequence available.

  • Chain 'F':
    No sequence available.

  • Chain 'G':
    No sequence available.

  • Chain 'H':
    Sequence, based on SEQRES records: (download)
    >3a6pH (H:)
    maaqgepqvqfklvlvgdggtgkttfvkrhltgefekkyvatlgvevhplvfhtnrgpik
    fnvwdtagqekfgglrdgyyiqaqcaiimfdvtsrvtyknvpnwhrdlvrvcenipivlc
    gnkvdikdrkvkaksivfhrkknlqyydisaksnynfekpflwlarkligdpnlefvamp
    alappevvmdpalaaqyehdlevaqttalpdedddl
    

    Sequence, based on observed residues (ATOM records): (download)
    >3a6pH (H:)
    pqvqfklvlvgdggtgkttfvkrhltgefekkyvatlgvevhplvfhtnrgpikfnvwdt
    agqekfgglrdgyyiqaqcaiimfdvtsrvtyknvpnwhrdlvrvcenipivlcgnkvdi
    kdrkvkaksivfhrkknlqyydisaksnynfekpflwlarkligdpnlef
    

  • Chain 'I':
    No sequence available.

  • Chain 'J':
    No sequence available.