SCOPe 2.06: Structural Classification of Proteins

PDB entry 3a2c

View 3a2c on RCSB PDB site
Description: Crystal structure of a pyrazolopyrimidine inhibitor complex bound to MAPKAP Kinase-2 (MK2)
Class: Transferase
Keywords: Gly-rich loop formed, aipha-helix, Alternative splicing, ATP-binding, Kinase, Nucleotide-binding, Phosphoprotein, Polymorphism, Serine/threonine-protein kinase, Transferase
Deposited on 2009-05-12, released 2010-05-12
The last revision prior to the SCOPe 2.06 freeze date was dated 2010-05-12, with a file datestamp of 2010-05-07.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: 0.288
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: MAP kinase-activated protein kinase 2
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot P49137
Domains in SCOPe 2.06: d3a2ca_
Chain 'B':
Compound: MAP kinase-activated protein kinase 2
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot P49137
Domains in SCOPe 2.06: d3a2cb_
Chain 'C':
Compound: MAP kinase-activated protein kinase 2
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot P49137
Domains in SCOPe 2.06: d3a2cc_
Chain 'D':
Compound: MAP kinase-activated protein kinase 2
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot P49137
Domains in SCOPe 2.06: d3a2cd_
Chain 'E':
Compound: MAP kinase-activated protein kinase 2
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot P49137
Domains in SCOPe 2.06: d3a2ce_
Chain 'F':
Compound: MAP kinase-activated protein kinase 2
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot P49137
Domains in SCOPe 2.06: d3a2cf_
Chain 'G':
Compound: MAP kinase-activated protein kinase 2
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot P49137
Domains in SCOPe 2.06: d3a2cg_
Chain 'H':
Compound: MAP kinase-activated protein kinase 2
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot P49137
Domains in SCOPe 2.06: d3a2ch_
Chain 'I':
Compound: MAP kinase-activated protein kinase 2
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot P49137
Domains in SCOPe 2.06: d3a2ci_
Chain 'J':
Compound: MAP kinase-activated protein kinase 2
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot P49137
Domains in SCOPe 2.06: d3a2cj_
Chain 'K':
Compound: MAP kinase-activated protein kinase 2
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot P49137
Domains in SCOPe 2.06: d3a2ck_
Chain 'L':
Compound: MAP kinase-activated protein kinase 2
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot P49137
Domains in SCOPe 2.06: d3a2cl_
Heterogens: PDY, SO4

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>3a2cA (A:)
qqfpqfhvksglqikknaiiddykvtsqvlglgingkvlqifnkrtqekfalkmlqdcpk
arrevelhwrasqcphivrivdvyenlyagrkcllivmecldggelfsriqdrgdqafte
reaseimksigeaiqylhsiniahrdvkpenllytskrpnailkltdfgfakettshnsl
ttpcytpyyvapevlgpekydkscdmwslgvimyillcgyppfysnhglaispgmktrir
mgqyefpnpewsevseevkmlirnllkteptqrmtitefmnhpwimqstkvpqtplhtsr
vlkedkerwedvkeemtsalatmr