PDB entry 2zwl

View 2zwl on RCSB PDB site
Description: Human factor viia-tissue factor complexed with highly selective peptide inhibitor
Class: hydrolase/blood clotting
Keywords: serine protease, alternative splicing, blood coagulation, calcium, cleavage on pair of basic residues, disease mutation, EGF-like domain, gamma-carboxyglutamic acid, glycoprotein, hydrolase, hydroxylation, pharmaceutical, polymorphism, protease, zymogen, lipoprotein, membrane, palmitate, transmembrane, HYDROLASE/BLOOD CLOTTING complex, Secreted
Deposited on 2008-12-16, released 2009-01-20
The last revision prior to the SCOPe 2.05 freeze date was dated 2009-01-20, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.226
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'H':
    Compound: Factor VII heavy chain
    Species: Homo sapiens [TaxId:9606]
    Gene: F7
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d2zwlh_
  • Chain 'L':
    Compound: Factor VII light chain
    Species: Homo sapiens [TaxId:9606]
    Gene: F7
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d2zwll1, d2zwll2, d2zwll3
  • Chain 'T':
    Compound: tissue factor
    Species: Homo sapiens [TaxId:9606]
    Gene: F3
    Database cross-references and differences (RAF-indexed):
  • Heterogens: BGC, FUC, CA, 567, HOH

PDB Chain Sequences:

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2zwlH (H:)
ivggkvcpkgecpwqvlllvngaqlcggtlintiwvvsaahcfdkiknwrnliavlgehd
lsehdgdeqsrrvaqviipstyvpgttnhdiallrlhqpvvltdhvvplclpertfsert
lafvrfslvsgwgqlldrgatalelmvlnvprlmtqdclqqsrkvgdspniteymfcagy
sdgskdsckgdsggphathyrgtwyltgivswgqgcatvghfgvytrvsqyiewlqklmr
seprpgvllrapfp

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >2zwlL (L:)
anafleelrpgslereckeeqcsfeeareifkdaertklfwisysdgdqcasspcqnggs
ckdqlqsyicfclpafegrncethkddqlicvnenggceqycsdhtgtkrscrchegysl
ladgvsctptveypcgkipilekrnaskpqgr

    Sequence, based on observed residues (ATOM records): (download) 
    >2zwlL (L:)
anafleelrpgslereckeeqcsfeeareifkdaertklfwisysdgdqcasspcqnggs
ckdqlqsyicfclpafegrncethkddqlicvnenggceqycsdhtgtkrscrchegysl
ladgvsctptveypcgkipile

  • Chain 'T':
    No sequence available.