PDB entry 2zqa

View 2zqa on RCSB PDB site
Description: Cefotaxime acyl-intermediate structure of class a beta-lacta Toho-1 E166A/R274N/R276N triple mutant
Class: hydrolase
Keywords: EXTENDED-SPECTRUM, ESBL, BETA-LACTAMASE, ACYL-ENZYME, COMPLEX, CEFOTAXIME, TOHO-1, HYDROLASE, Antibiotic resistance
Deposited on 2008-08-07, released 2009-07-28
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-09-19, with a file datestamp of 2018-09-14.
Experiment type: XRAY
Resolution: 0.95 Å
R-factor: N/A
AEROSPACI score: 0.87 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: beta-lactamase toho-1
    Species: Escherichia coli [TaxId:562]
    Gene: bla
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q47066 (Start-261)
      • engineered mutation (139)
      • engineered mutation (245)
      • engineered mutation (247)
    Domains in SCOPe 2.08: d2zqaa_
  • Heterogens: CEF, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2zqaA (A:)
ansvqqqlealekssggrlgvalintadnsqilyraderfamcstskvmaaaavlkqses
dkhllnqrveikksdlvnynpiaekhvngtmtlaelgaaalqysdntamnkliahlggpd
kvtafarslgdetfrldrtaptlntaipgdprdtttplamaqtlknltlgkalaetqraq
lvtwlkgnttgsasiraglpkswvvgdktgsgdygttndiaviwpenhaplvlvtyftqp
eqkaenrndilaaaakivthgf

    Sequence, based on observed residues (ATOM records): (download) 
    >2zqaA (A:)
nsvqqqlealekssggrlgvalintadnsqilyraderfamcstskvmaaaavlkqsesd
khllnqrveikksdlvnynpiaekhvngtmtlaelgaaalqysdntamnkliahlggpdk
vtafarslgdetfrldrtaptlntaipgdprdtttplamaqtlknltlgkalaetqraql
vtwlkgnttgsasiraglpkswvvgdktgsgdygttndiaviwpenhaplvlvtyftqpe
qkaenrndilaaaakivthgf