PDB entry 2zm1

View 2zm1 on RCSB PDB site
Description: Crystal structure of imidazo pyrazin 1 bound to the kinase domain of human LCK, (auto-phosphorylated on TYR394)
Class: transferase
Keywords: Tyrosine-protein kinase, ATP-binding, Phosphorylation, Signal transduction, Alternative splicing, Chromosomal rearrangement, Cytoplasm, Disease mutation, Host-virus interaction, Lipoprotein, Membrane, Myristate, Nucleotide-binding, Palmitate, Phosphoprotein, Proto-oncogene, SH2 domain, SH3 domain, Transferase
Deposited on 2008-04-10, released 2008-10-14
The last revision prior to the SCOP 1.75 freeze date was dated 2009-02-03, with a file datestamp of 2009-01-30.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.172
AEROSPACI score: 0.54 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Proto-oncogene tyrosine-protein kinase LCK
    Species: Homo sapiens [TaxId:9606]
    Gene: LCK
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d2zm1a1
  • Heterogens: SO4, DMS, KSF, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2zm1A (A:)
qtqkpqkpwwedewevpretlklverlgagqfgevwmgyynghtkvavkslkqgsmspda
flaeanlmkqlqhqrlvrlyavvtqepiyiiteymengslvdflktpsgikltinklldm
aaqiaegmafieernyihrdlraanilvsdtlsckiadfglarliedneytaregakfpi
kwtapeainygtftiksdvwsfgillteivthgripypgmtnpeviqnlergyrmvrpdn
cpeelyqlmrlcwkerpedrptfdylrsvledfftategqyqpqp

    Sequence, based on observed residues (ATOM records): (download) 
    >2zm1A (A:)
kpwwedewevpretlklverlgagqfgevwmgyynghtkvavkslkqgsmspdaflaean
lmkqlqhqrlvrlyavvtqepiyiiteymengslvdflktpsgikltinklldmaaqiae
gmafieernyihrdlraanilvsdtlsckiadfglarliedneytaregakfpikwtape
ainygtftiksdvwsfgillteivthgripypgmtnpeviqnlergyrmvrpdncpeely
qlmrlcwkerpedrptfdylrsvledfftat