PDB entry 2zir

View 2zir on RCSB PDB site
Description: Crystal Structure of rat protein farnesyltransferase complexed with a benzofuran inhibitor and FPP
Class: transferase
Keywords: Prenyltransferase, Transferase, Metal-binding, Phosphoprotein
Deposited on 2008-02-22, released 2009-02-24
The last revision prior to the SCOPe 2.07 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.195
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Protein farnesyltransferase subunit alpha
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Fnta
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q04631
      • engineered mutation (155)
    Domains in SCOPe 2.07: d2zira_
  • Chain 'B':
    Compound: Protein farnesyltransferase subunit beta
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Fntb
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d2zirb_
  • Heterogens: ZN, FPP, NH7, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2zirA (A:)
    maategvgesapggepgqpeqpppppppppaqqpqeeemaaeageaaaspmddgflslds
    ptyvlyrdraewadidpvpqndgpspvvqiiysekfrdvydyfravlqrderserafklt
    rdaielnaanytvwhfrrvllrslqkdlqeemnyitaiieeqpknyqvwhhrrvlvewlk
    dpsqelefiadilnqdaknyhawqhrqwviqefrlwdnelqyvdqllkedvrnnsvwnqr
    hfvisnttgysdravlerevqytlemiklvphnesawnylkgilqdrglsrypnllnqll
    dlqpshsspyliaflvdiyedmlenqcdnkedilnkalelceilakekdtirkeywryig
    rslqskhsresdipasv
    

    Sequence, based on observed residues (ATOM records): (download)
    >2zirA (A:)
    flsldsptyvlyrdraewadidpvpqndgpspvvqiiysekfrdvydyfravlqrderse
    rafkltrdaielnaanytvwhfrrvllrslqkdlqeemnyitaiieeqpknyqvwhhrrv
    lvewlkdpsqelefiadilnqdaknyhawqhrqwviqefrlwdnelqyvdqllkedvrnn
    svwnqrhfvisnttgysdravlerevqytlemiklvphnesawnylkgilqdrglsrypn
    llnqlldlqpshsspyliaflvdiyedmlenqcdnkedilnkalelceilakekdtirke
    ywryigrslqskhs
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >2zirB (B:)
    gshmassssftyycppssspvwseplyslrpeharerlqddsvetvtsieqakveekiqe
    vfssykfnhlvprlvlqrekhfhylkrglrqltdayecldasrpwlcywilhslelldep
    ipqivatdvcqflelcqspdggfgggpgqyphlaptyaavnalciigteeaynvinrekl
    lqylyslkqpdgsflmhvggevdvrsaycaasvasltniitpdlfegtaewiarcqnweg
    giggvpgmeahggytfcglaalvilkkerslnlksllqwvtsrqmrfeggfqgrcnklvd
    gcysfwqagllpllhralhaqgdpalsmshwmfhqqalqeyilmccqcpagglldkpgks
    rdfyhtcyclsglsiaqhfgsgamlhdvvmgvpenvlqpthpvynigpdkviqatthflq
    kpvpgfeecedavtsdpatd
    

    Sequence, based on observed residues (ATOM records): (download)
    >2zirB (B:)
    eplyslrpeharerlqddsvetvtsieqakveekiqevfssykfnhlvprlvlqrekhfh
    ylkrglrqltdayecldasrpwlcywilhslelldepipqivatdvcqflelcqspdggf
    gggpgqyphlaptyaavnalciigteeaynvinrekllqylyslkqpdgsflmhvggevd
    vrsaycaasvasltniitpdlfegtaewiarcqnweggiggvpgmeahggytfcglaalv
    ilkkerslnlksllqwvtsrqmrfeggfqgrcnklvdgcysfwqagllpllhralhaqgd
    palsmshwmfhqqalqeyilmccqcpagglldkpgksrdfyhtcyclsglsiaqhfgsga
    mlhdvvmgvpenvlqpthpvynigpdkviqatthflqkpvpg