PDB entry 2zia

View 2zia on RCSB PDB site
Description: C4S dCK variant of dCK in complex with cladribine+UDP
Class: transferase
Keywords: dCK, purine, deoxycytidine kinase, nucleoside, cladribine, 2-chloro-2'-deoxyadenosine, deoxyadenosine analog, UDP, ATP-binding, Nucleotide-binding, Nucleus, Phosphoprotein, Transferase
Deposited on 2008-02-13, released 2008-07-08
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.207
AEROSPACI score: 0.47 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Deoxycytidine kinase
    Species: Homo sapiens [TaxId:9606]
    Gene: DCK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P27707 (Start-278)
      • engineered (63)
      • engineered (77)
      • engineered (164)
    Domains in SCOPe 2.08: d2ziaa_
  • Chain 'B':
    Compound: Deoxycytidine kinase
    Species: Homo sapiens [TaxId:9606]
    Gene: DCK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P27707 (Start-278)
      • engineered (63)
      • engineered (77)
      • engineered (164)
    Domains in SCOPe 2.08: d2ziab_
  • Heterogens: UDP, CL9, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2ziaA (A:)
mgsshhhhhhsglvprgshmatppkrsspsfsassegtrikkisiegniaagkstfvnil
kqlsedwevvpepvarwsnvqstqdefeeltmsqknggnvlqmmyekperwsftfqtyac
lsriraqlaslngklkdaekpvlffersvysdryifasnlyesesmnetewtiyqdwhdw
mnnqfgqsleldgiiylqatpetclhriylrgrneeqgipleyleklhykheswllhrtl
ktnfdylqevpiltldvnedfkdkyeslvekvkeflstl

    Sequence, based on observed residues (ATOM records): (download) 
    >2ziaA (A:)
rikkisiegniaagkstfvnilkqlsedwevvpepvarwsnvggnvlqmmyekperwsft
fqtyaclsriraqlaslnaekpvlffersvysdryifasnlyesesmnetewtiyqdwhd
wmnnqfgqsleldgiiylqatpetclhriylrgrneeqgipleyleklhykheswllhrt
lktnfdylqevpiltldvnedfkdkyeslvekvkeflstl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2ziaB (B:)
mgsshhhhhhsglvprgshmatppkrsspsfsassegtrikkisiegniaagkstfvnil
kqlsedwevvpepvarwsnvqstqdefeeltmsqknggnvlqmmyekperwsftfqtyac
lsriraqlaslngklkdaekpvlffersvysdryifasnlyesesmnetewtiyqdwhdw
mnnqfgqsleldgiiylqatpetclhriylrgrneeqgipleyleklhykheswllhrtl
ktnfdylqevpiltldvnedfkdkyeslvekvkeflstl

    Sequence, based on observed residues (ATOM records): (download) 
    >2ziaB (B:)
rikkisiegniaagkstfvnilkqlsedwevvpepvarwsnvqstggnvlqmmyekperw
sftfqtyaclsriraqlaslnldaekpvlffersvysdryifasnlyesesmnetewtiy
qdwhdwmnnqfgqsleldgiiylqatpetclhriylrgrneeqgipleyleklhykhesw
llhrtltylqevpiltldvnedfkdkyeslvekvkeflstl