PDB entry 2zi9

View 2zi9 on RCSB PDB site
Description: C4S-E247A dCK variant of dCK in complex with cladribine+ADP
Class: transferase
Keywords: dCK, purine, cladribine, deoxycytidine kinase, nucleoside, deoxyadenosine analog, ATP-binding, Nucleotide-binding, Nucleus, Phosphoprotein, Transferase
Deposited on 2008-02-13, released 2008-07-08
The last revision prior to the SCOPe 2.04 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.51 Å
R-factor: 0.239
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Deoxycytidine kinase
    Species: Homo sapiens [TaxId:9606]
    Gene: DCK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P27707 (Start-278)
      • engineered (63)
      • engineered (77)
      • engineered (164)
      • engineered (265)
    Domains in SCOPe 2.04: d2zi9a_
  • Chain 'B':
    Compound: Deoxycytidine kinase
    Species: Homo sapiens [TaxId:9606]
    Gene: DCK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P27707 (Start-278)
      • engineered (63)
      • engineered (77)
      • engineered (164)
      • engineered (265)
    Domains in SCOPe 2.04: d2zi9b_
  • Heterogens: ADP, CL9, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2zi9A (A:)
mgsshhhhhhsglvprgshmatppkrsspsfsassegtrikkisiegniaagkstfvnil
kqlsedwevvpepvarwsnvqstqdefeeltmsqknggnvlqmmyekperwsftfqtyac
lsriraqlaslngklkdaekpvlffersvysdryifasnlyesesmnetewtiyqdwhdw
mnnqfgqsleldgiiylqatpetclhriylrgrneeqgipleyleklhykheswllhrtl
ktnfdylqevpiltldvnedfkdkyaslvekvkeflstl

    Sequence, based on observed residues (ATOM records): (download) 
    >2zi9A (A:)
trikkisiegniaagkstfvnilkqlsedwevvpepvarwsnvqstqdefeeltmsqkng
gnvlqmmyekperwsftfqtyaclsriraqlaslngklkdaekpvlffersvysdryifa
snlyesesmnetewtiyqdwhdwmnnqfgqsleldgiiylqatpetclhriylrgrneeq
gipleyleklhykheswllhrtlktnfdylqevpiltldvnedfkdkyaslvekvkefls
tl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2zi9B (B:)
mgsshhhhhhsglvprgshmatppkrsspsfsassegtrikkisiegniaagkstfvnil
kqlsedwevvpepvarwsnvqstqdefeeltmsqknggnvlqmmyekperwsftfqtyac
lsriraqlaslngklkdaekpvlffersvysdryifasnlyesesmnetewtiyqdwhdw
mnnqfgqsleldgiiylqatpetclhriylrgrneeqgipleyleklhykheswllhrtl
ktnfdylqevpiltldvnedfkdkyaslvekvkeflstl

    Sequence, based on observed residues (ATOM records): (download) 
    >2zi9B (B:)
trikkisiegniaagkstfvnilkqlsedwevvpepvarwsnvqnggnvlqmmyekperw
sftfqtyaclsriraqlaslngklkdaekpvlffersvysdryifasnlyesesmnetew
tiyqdwhdwmnnqfgqsleldgiiylqatpetclhriylrgrneeqgipleyleklhykh
eswllhrtlktnfdylqevpiltldvnedfkdkyaslvekvkeflstl