PDB entry 2zi6

View 2zi6 on RCSB PDB site
Description: C4S dCK variant of dCK in complex with D-dA+UDP
Class: transferase
Keywords: dCK, purine, deoxyadenosine, deoxycytidine kinase, nucleoside, enantiomer, D-dA, UDP, ATP-binding, Nucleotide-binding, Nucleus, Phosphoprotein, Transferase
Deposited on 2008-02-13, released 2008-04-22
The last revision prior to the SCOPe 2.07 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 1.77 Å
R-factor: 0.208
AEROSPACI score: 0.44 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Deoxycytidine kinase
    Species: Homo sapiens [TaxId:9606]
    Gene: DCK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P27707
      • engineered (63)
      • engineered (164)
    Domains in SCOPe 2.07: d2zi6a_
  • Chain 'B':
    Compound: Deoxycytidine kinase
    Species: Homo sapiens [TaxId:9606]
    Gene: DCK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P27707
      • engineered (63)
      • engineered (77)
      • engineered (164)
    Domains in SCOPe 2.07: d2zi6b_
  • Chain 'C':
    Compound: Deoxycytidine kinase
    Species: Homo sapiens [TaxId:9606]
    Gene: DCK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P27707
      • engineered (63)
      • engineered (77)
      • engineered (164)
    Domains in SCOPe 2.07: d2zi6c_
  • Chain 'D':
    Compound: Deoxycytidine kinase
    Species: Homo sapiens [TaxId:9606]
    Gene: DCK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P27707 (Start-278)
      • engineered (63)
      • engineered (164)
    Domains in SCOPe 2.07: d2zi6d_
  • Heterogens: UDP, 3D1, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2zi6A (A:)
mgsshhhhhhsglvprgshmatppkrsspsfsassegtrikkisiegniaagkstfvnil
kqlsedwevvpepvarwsnvqstqdefeeltmsqknggnvlqmmyekperwsftfqtyac
lsriraqlaslngklkdaekpvlffersvysdryifasnlyesesmnetewtiyqdwhdw
mnnqfgqsleldgiiylqatpetclhriylrgrneeqgipleyleklhykheswllhrtl
ktnfdylqevpiltldvnedfkdkyeslvekvkeflstl

    Sequence, based on observed residues (ATOM records): (download) 
    >2zi6A (A:)
rikkisiegniaagkstfvnilkqlsedwevvpepvarwggnvlqmmyekperwsftfqt
yaclsriraqlaslnaekpvlffersvysdryifasnlyesesmnetewtiyqdwhdwmn
nqfgqsleldgiiylqatpetclhriylrgrneeqgipleyleklhykheswllhrtlkt
nfdylqevpiltldvnedfkdkyeslvekvkeflstl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2zi6B (B:)
mgsshhhhhhsglvprgshmatppkrsspsfsassegtrikkisiegniaagkstfvnil
kqlsedwevvpepvarwsnvqstqdefeeltmsqknggnvlqmmyekperwsftfqtyac
lsriraqlaslngklkdaekpvlffersvysdryifasnlyesesmnetewtiyqdwhdw
mnnqfgqsleldgiiylqatpetclhriylrgrneeqgipleyleklhykheswllhrtl
ktnfdylqevpiltldvnedfkdkyeslvekvkeflstl

    Sequence, based on observed residues (ATOM records): (download) 
    >2zi6B (B:)
rikkisiegniaagkstfvnilkqlsedwevvpepvarwsnvtmsqknggnvlqmmyekp
erwsftfqtyaclsriraqlaslngklekpvlffersvysdryifasnlyesesmnetew
tiyqdwhdwmnnqsleldgiiylqatpetclhriylrgrneeqgipleyleklhykhesw
llhrtlktnfdylqevpiltldvnedfkdkyeslvekvkeflstl

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2zi6C (C:)
mgsshhhhhhsglvprgshmatppkrsspsfsassegtrikkisiegniaagkstfvnil
kqlsedwevvpepvarwsnvqstqdefeeltmsqknggnvlqmmyekperwsftfqtyac
lsriraqlaslngklkdaekpvlffersvysdryifasnlyesesmnetewtiyqdwhdw
mnnqfgqsleldgiiylqatpetclhriylrgrneeqgipleyleklhykheswllhrtl
ktnfdylqevpiltldvnedfkdkyeslvekvkeflstl

    Sequence, based on observed residues (ATOM records): (download) 
    >2zi6C (C:)
rikkisiegniaagkstfvnilkqlsedwevvpepvarwsknggnvlqmmyekperwsft
fqtyaclsriraqlaslnekpvlffersvysdryifasnlyesesmnetewtiyqdwhdw
mnnqfleldgiiylqatpetclhriylrgrneeqgipleyleklhykheswllhrtlktn
fdylqevpiltldvnedfkdkyeslvekvkeflstl

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2zi6D (D:)
mgsshhhhhhsglvprgshmatppkrsspsfsassegtrikkisiegniaagkstfvnil
kqlsedwevvpepvarwsnvqstqdefeeltmsqknggnvlqmmyekperwsftfqtyac
lsriraqlaslngklkdaekpvlffersvysdryifasnlyesesmnetewtiyqdwhdw
mnnqfgqsleldgiiylqatpetclhriylrgrneeqgipleyleklhykheswllhrtl
ktnfdylqevpiltldvnedfkdkyeslvekvkeflstl

    Sequence, based on observed residues (ATOM records): (download) 
    >2zi6D (D:)
rikkisiegniaagkstfvnilkqlsedwevvpepvarwnggnvlqmmyekperwsftfq
tyaclsriraqlaslngklekpvlffersvysdryifasnlyesesmnetewtiyqdwhd
wmnnqfgleldgiiylqatpetclhriylrgrneeqgipleyleklhykheswllhrtlk
tnfdylqevpiltldvnedfkdkyeslvekvkeflstl