SCOPe 2.06: Structural Classification of Proteins

PDB entry 2zhx

View 2zhx on RCSB PDB site
Description: Crystal structure of Uracil-DNA Glycosylase from Mycobacterium tuberculosis in complex with a proteinaceous inhibitor
Class: hydrolase/hydrolase inhibitor
Keywords: DNA repair, Ung-Ugi complex, Ung-DNA interactions, DNA damage, Glycosidase, Hydrolase, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
Deposited on 2008-02-11, released 2008-05-20
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 3.1 Å
R-factor: 0.236
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: uracil-DNA glycosylase
Species: MYCOBACTERIUM TUBERCULOSIS
Gene: ung, Rv2976c
Database cross-references and differences (RAF-indexed):
- Uniprot P67071 (Start-237)
Domains in SCOPe 2.06: d2zhxa_
Chain 'B':
Compound: uracil-DNA glycosylase inhibitor
Species: BACTERIOPHAGE PBS2
Gene: ugi, J04434
Database cross-references and differences (RAF-indexed):
- Uniprot P14739 (Start-83)
Domains in SCOPe 2.06: d2zhxb_
Chain 'C':
Compound: uracil-DNA glycosylase
Species: MYCOBACTERIUM TUBERCULOSIS
Gene: ung, Rv2976c
Database cross-references and differences (RAF-indexed):
- Uniprot P67071 (Start-237)
Domains in SCOPe 2.06: d2zhxc_
Chain 'D':
Compound: uracil-DNA glycosylase inhibitor
Species: BACTERIOPHAGE PBS2
Gene: ugi, J04434
Database cross-references and differences (RAF-indexed):
- Uniprot P14739 (Start-83)
Domains in SCOPe 2.06: d2zhxd_
Chain 'E':
Compound: uracil-DNA glycosylase
Species: MYCOBACTERIUM TUBERCULOSIS
Gene: ung, Rv2976c
Database cross-references and differences (RAF-indexed):
- Uniprot P67071 (Start-237)
Domains in SCOPe 2.06: d2zhxe_
Chain 'F':
Compound: uracil-DNA glycosylase inhibitor
Species: BACTERIOPHAGE PBS2
Gene: ugi, J04434
Database cross-references and differences (RAF-indexed):
- Uniprot P14739 (Start-83)
Domains in SCOPe 2.06: d2zhxf_
Chain 'G':
Compound: uracil-DNA glycosylase
Species: MYCOBACTERIUM TUBERCULOSIS
Gene: ung, Rv2976c
Database cross-references and differences (RAF-indexed):
- Uniprot P67071 (Start-237)
Domains in SCOPe 2.06: d2zhxg_
Chain 'H':
Compound: uracil-DNA glycosylase inhibitor
Species: BACTERIOPHAGE PBS2
Gene: ugi, J04434
Database cross-references and differences (RAF-indexed):
- Uniprot P14739 (Start-83)
Domains in SCOPe 2.06: d2zhxh_
Chain 'I':
Compound: uracil-DNA glycosylase
Species: MYCOBACTERIUM TUBERCULOSIS
Gene: ung, Rv2976c
Database cross-references and differences (RAF-indexed):
- Uniprot P67071 (Start-237)
Domains in SCOPe 2.06: d2zhxi_
Chain 'J':
Compound: uracil-DNA glycosylase inhibitor
Species: BACTERIOPHAGE PBS2
Gene: ugi, J04434
Database cross-references and differences (RAF-indexed):
- Uniprot P14739 (Start-83)
Domains in SCOPe 2.06: d2zhxj_
Chain 'K':
Compound: uracil-DNA glycosylase
Species: MYCOBACTERIUM TUBERCULOSIS
Gene: ung, Rv2976c
Database cross-references and differences (RAF-indexed):
- Uniprot P67071 (Start-237)
Domains in SCOPe 2.06: d2zhxk_
Chain 'L':
Compound: uracil-DNA glycosylase inhibitor
Species: BACTERIOPHAGE PBS2
Gene: ugi, J04434
Database cross-references and differences (RAF-indexed):
- Uniprot P14739 (Start-83)
Domains in SCOPe 2.06: d2zhxl_
Chain 'M':
Compound: uracil-DNA glycosylase
Species: MYCOBACTERIUM TUBERCULOSIS
Gene: ung, Rv2976c
Database cross-references and differences (RAF-indexed):
- Uniprot P67071 (Start-237)
Domains in SCOPe 2.06: d2zhxm_
Chain 'N':
Compound: uracil-DNA glycosylase inhibitor
Species: BACTERIOPHAGE PBS2
Gene: ugi, J04434
Database cross-references and differences (RAF-indexed):
- Uniprot P14739 (Start-83)
Domains in SCOPe 2.06: d2zhxn_
Heterogens: HOH

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>2zhxA (A:)
mhhhhhhgmasmtarplselvergwaaalepvadqvahmgqflraeiaagrrylpagsnv
lraftfpfdnvrvlivgqdpyptpghavglsfsvapdvrpwprslanifdeytadlgypl
psngdltpwaqrgvlllnrvltvrpsnpashrgkgweavtecairalaaraaplvailwg
rdastlkpmlaagncvaiesphpsplsasrgffgsrpfsranellvgmgaepidwrlp