PDB entry 2zej

View 2zej on RCSB PDB site
Description: Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase
Class: transferase
Keywords: Parkinson's Disease, LRRK2, ROC, GTPase, ROCO, Kinase, ATP-binding, Disease mutation, GTP-binding, GTPase activation, Leucine-rich repeat, Membrane, Nucleotide-binding, Parkinson disease, Serine/threonine-protein kinase, Transferase
Deposited on 2007-12-13, released 2008-01-22
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-10-11, with a file datestamp of 2017-10-06.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Leucine-rich repeat kinase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: LRRK2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2zeja_
  • Chain 'B':
    Compound: Leucine-rich repeat kinase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: LRRK2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2zejb_
  • Heterogens: MG, GDP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2zejA (A:)
nrmklmivgntgsgkttllqqlmktkksdlgmqsatvgidvkdwpiqirdkrkrdlvlnv
wdfagreefysthphfmtqralylavydlskgqaevdamkpwlfnikarassspvilvgt
hldvsdekqrkacmskitkellnkrgfpairdyhfvnateesdalaklrktiineslnfk
irdq

    Sequence, based on observed residues (ATOM records): (download) 
    >2zejA (A:)
mklmivgntgsgkttllqqlmktvgidvkdwpilvlnvwdfagreefysthphfmtqral
ylavydlskgqaevdamkpwlfnikarassspvilvgthldvsdekqrkacmskitkell
nkrgfpairdyhfvnateesdalaklrktiineslnf

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2zejB (B:)
nrmklmivgntgsgkttllqqlmktkksdlgmqsatvgidvkdwpiqirdkrkrdlvlnv
wdfagreefysthphfmtqralylavydlskgqaevdamkpwlfnikarassspvilvgt
hldvsdekqrkacmskitkellnkrgfpairdyhfvnateesdalaklrktiineslnfk
irdq

    Sequence, based on observed residues (ATOM records): (download) 
    >2zejB (B:)
mklmivgntgsgkttllqqlmktqsatvgidvkdwpilvlnvwdfagreefysthphfmt
qralylavydlskgqaevdamkpwlfnikarassspvilvgthldvsdekqrkacmskit
kellnkrgfpairdyhfvnateesdalaklrktiineslnfk