PDB entry 2zee

View 2zee on RCSB PDB site
Description: Crystal structure of the human glutaminyl cyclase mutant S160G at 1.99 angstrom resolution
Class: transferase
Keywords: hydrogen bond network, glutaminyl cyclase, pyroglutamate, site-directed mutagenesis, proton transfer, TRANSFERASE
Deposited on 2007-12-12, released 2008-04-22
The last revision prior to the SCOPe 2.07 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 1.99 Å
R-factor: 0.176
AEROSPACI score: 0.47 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Glutaminyl-peptide cyclotransferase
    Species: Homo sapiens [TaxId:9606]
    Gene: QPCT
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16769 (0-328)
      • engineered (127)
    Domains in SCOPe 2.07: d2zeea_
  • Chain 'B':
    Compound: Glutaminyl-peptide cyclotransferase
    Species: Homo sapiens [TaxId:9606]
    Gene: QPCT
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16769 (0-328)
      • engineered (127)
    Domains in SCOPe 2.07: d2zeeb_
  • Heterogens: ZN, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2zeeA (A:)
asawpeeknyhqpailnssalrqiaegtsisemwqndlqpllierypgspgsyaarqhim
qriqrlqadwvleidtflsqtpygyrsfsniistlnptakrhlvlachydskyfshwnnr
vfvgatdgavpcammlelaraldkkllslktvsdskpdlslqliffdgeeaflhwspqds
lygsrhlaakmastphppgargtsqlhgmdllvlldligapnptfpnffpnsarwferlq
aiehelhelgllkdhslegryfqnysyggviqddhipflrrgvpvlhlipspfpevwhtm
ddneenldestidnlnkilqvfvleylhl

    Sequence, based on observed residues (ATOM records): (download) 
    >2zeeA (A:)
asawpeeknyhqpailnssalrqiaegtsisemwqndlqpllierypgspgsyaarqhim
qriqrlqadwvleidtflsqtpygyrsfsniistlnptakrhlvlachydskyfshwnnr
vfvgatdgavpcammlelaraldkkllslkpdlslqliffdgeeaflhwspqdslygsrh
laakmastphppgargtsqlhgmdllvlldligapnptfpnffpnsarwferlqaiehel
helgllkdhslegryfqnysyggviqddhipflrrgvpvlhlipspfpevwhtmddneen
ldestidnlnkilqvfvleylhl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2zeeB (B:)
asawpeeknyhqpailnssalrqiaegtsisemwqndlqpllierypgspgsyaarqhim
qriqrlqadwvleidtflsqtpygyrsfsniistlnptakrhlvlachydskyfshwnnr
vfvgatdgavpcammlelaraldkkllslktvsdskpdlslqliffdgeeaflhwspqds
lygsrhlaakmastphppgargtsqlhgmdllvlldligapnptfpnffpnsarwferlq
aiehelhelgllkdhslegryfqnysyggviqddhipflrrgvpvlhlipspfpevwhtm
ddneenldestidnlnkilqvfvleylhl

    Sequence, based on observed residues (ATOM records): (download) 
    >2zeeB (B:)
asawpeeknyhqpailnssalrqiaegtsisemwqndlqpllierypgspgsyaarqhim
qriqrlqadwvleidtflsqtpygyrsfsniistlnptakrhlvlachydskyfshwnnr
vfvgatdgavpcammlelaraldkkllslkpdlslqliffdgeeaflhwspqdslygsrh
laakmastphppgargtsqlhgmdllvlldligapnptfpnffpnsarwferlqaiehel
helgllkdhslegryfqnysyggviqddhipflrrgvpvlhlipspfpevwhtmddneen
ldestidnlnkilqvfvleylhl