PDB entry 2zdy

View 2zdy on RCSB PDB site
Description: Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4
Class: transferase
Keywords: PDK4, KINASE, ATP-BINDING, ADP, Carbohydrate metabolism, Glucose metabolism, Mitochondrion, Phosphoprotein, Transferase, Transit peptide
Deposited on 2007-12-01, released 2008-12-09
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-10-11, with a file datestamp of 2017-10-06.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Pyruvate dehydrogenase kinase isozyme 4
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16654 (2-End)
      • expression tag (1)
    Domains in SCOPe 2.08: d2zdya1, d2zdya2, d2zdya3
  • Chain 'B':
    Compound: Pyruvate dehydrogenase kinase isozyme 4
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2zdyb1, d2zdyb2
  • Heterogens: MG, ADP, EPE, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2zdyA (A:)
gpvprevehfsryspsplsmkqlldfgsenacertsfaflrqelpvrlanilkeidilpt
qlvntssvqlvkswyiqslmdlvefhekspddqkalsdfvdtlikvrnrhhnvvptmaqg
iieykdactvdpvtnqnlqyfldrfymnristrmlmnqhilifsdsqtgnpshigsidpn
cdvvavvqdafecsrmlcdqyylsspelkltqvngkfpdqpihivyvpshlhhmlfelfk
namratvehqenqpsltpievivvlgkedltikisdrgggvplriidrlfsytystaptp
vmdnsrnaplagfgyglpisrlyakyfqgdlnlyslsgygtdaiiylkalssesieklpv
fnksafkhyqmsseaddwcipsrepknlakevam

    Sequence, based on observed residues (ATOM records): (download) 
    >2zdyA (A:)
pvprevehfsryspsplsmkqlldfgscertsfaflrqelpvrlanilkeidilptqlvn
tssvqlvkswyiqslmdlvefhekspddqkalsdfvdtlikvrnrhhnvvptmaqgiiey
ktvdpvtnqnlqyfldrfymnristrmlmnqhilifsdsqtgnpshigsidpncdvvavv
qdafecsrmlcdqyylsspelkltqvngkfpdqpihivyvpshlhhmlfelfknamratv
ehqenqpsltpievivvlgkedltikisdrgggvplriidrlfsytystaptpplagfgy
glpisrlyakyfqgdlnlyslsgygtdaiiylkalssesieklpvfnksafkhy

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2zdyB (B:)
gpvprevehfsryspsplsmkqlldfgsenacertsfaflrqelpvrlanilkeidilpt
qlvntssvqlvkswyiqslmdlvefhekspddqkalsdfvdtlikvrnrhhnvvptmaqg
iieykdactvdpvtnqnlqyfldrfymnristrmlmnqhilifsdsqtgnpshigsidpn
cdvvavvqdafecsrmlcdqyylsspelkltqvngkfpdqpihivyvpshlhhmlfelfk
namratvehqenqpsltpievivvlgkedltikisdrgggvplriidrlfsytystaptp
vmdnsrnaplagfgyglpisrlyakyfqgdlnlyslsgygtdaiiylkalssesieklpv
fnksafkhyqmsseaddwcipsrepknlakevam

    Sequence, based on observed residues (ATOM records): (download) 
    >2zdyB (B:)
prevehfsryspsplsmkqlldfgsenacertsfaflrqelpvrlanilkeidilptqlv
ntssvqlvkswyiqslmdlvefhekspddqkalsdfvdtlikvrnrhhnvvptmaqgiie
ykdactvdpvtnqnlqyfldrfymnristrmlmnqhilifstgnpshigsidpncdvvav
vqdafecsrmlcdqyylsspelkltqvngkfpdqpihivyvpshlhhmlfelfknamrat
vehqenqpsltpievivvlgkedltikisdrgggvplriidrlfsytystgfgyglpisr
lyakyfqgdlnlyslsgygtdaiiylkalssesieklpvfnksafkhyddwcip