PDB entry 2zdx

View 2zdx on RCSB PDB site
Description: Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4
Class: transferase
Keywords: PDK4, KINASE, ATP-BINDING, INHIBITOR, Carbohydrate metabolism, Glucose metabolism, Mitochondrion, Phosphoprotein, Transferase, Transit peptide
Deposited on 2007-11-30, released 2008-12-09
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-11-23, with a file datestamp of 2011-11-18.
Experiment type: XRAY
Resolution: 2.54 Å
R-factor: 0.222
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Pyruvate dehydrogenase kinase isozyme 4
    Species: Homo sapiens [TaxId:9606]
    Gene: PDK4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d2zdxa1, d2zdxa2
  • Chain 'B':
    Compound: Pyruvate dehydrogenase kinase isozyme 4
    Species: Homo sapiens [TaxId:9606]
    Gene: PDK4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d2zdxb1, d2zdxb2
  • Heterogens: P4A, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2zdxA (A:)
    gpvprevehfsryspsplsmkqlldfgsenacertsfaflrqelpvrlanilkeidilpt
    qlvntssvqlvkswyiqslmdlvefhekspddqkalsdfvdtlikvrnrhhnvvptmaqg
    iieykdactvdpvtnqnlqyfldrfymnristrmlmnqhilifsdsqtgnpshigsidpn
    cdvvavvqdafecsrmlcdqyylsspelkltqvngkfpdqpihivyvpshlhhmlfelfk
    namratvehqenqpsltpievivvlgkedltikisdrgggvplriidrlfsytystaptp
    vmdnsrnaplagfgyglpisrlyakyfqgdlnlyslsgygtdaiiylkalssesieklpv
    fnksafkhyqmsseaddwcipsrepknlakevam
    

    Sequence, based on observed residues (ATOM records): (download)
    >2zdxA (A:)
    vprevehfsryspsplsmkqlldfgsenacertsfaflrqelpvrlanilkeidilptql
    vntssvqlvkswyiqslmdlvefhekspddqkalsdfvdtlikvrnrhhnvvptmaqgii
    eynqnlqyfldrfymnristrmlmnqhilifsdsqtgnpshigsidpncdvvavvqdafe
    csrmlcdqyylsspelkltqvngkfpdqpihivyvpshlhhmlfelfknamratvehqen
    qpsltpievivvlgkedltikisdrgggvplriidrlfsytfgyglpisrlyakyfqgdl
    nlyslsgygtdaiiylkalssesieklpvfnksafkh
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >2zdxB (B:)
    gpvprevehfsryspsplsmkqlldfgsenacertsfaflrqelpvrlanilkeidilpt
    qlvntssvqlvkswyiqslmdlvefhekspddqkalsdfvdtlikvrnrhhnvvptmaqg
    iieykdactvdpvtnqnlqyfldrfymnristrmlmnqhilifsdsqtgnpshigsidpn
    cdvvavvqdafecsrmlcdqyylsspelkltqvngkfpdqpihivyvpshlhhmlfelfk
    namratvehqenqpsltpievivvlgkedltikisdrgggvplriidrlfsytystaptp
    vmdnsrnaplagfgyglpisrlyakyfqgdlnlyslsgygtdaiiylkalssesieklpv
    fnksafkhyqmsseaddwcipsrepknlakevam
    

    Sequence, based on observed residues (ATOM records): (download)
    >2zdxB (B:)
    vprevehfsryspsplsmkqlldfgsenacertsfaflrqelpvrlanilkeidilptql
    vtssvqlvkswyiqslmdlvefhekspddqkalsdfvdtlikvrnrhhnvvptmaqgiey
    kdactvdpvtnqnlqyfldrfymnristrmlmnqhilifsdqtgnpshigsidpncdvva
    vvqdafecsrmlcdqyylsspelkltqvngkfpdqpihivyvpshlhhmlfelfknamra
    tvehqenqpsltpievivvlgkedltikisdrgggvplriidrlfsyyglpisrlyakyf
    qgdlnlyslsgygtdaiiylkalssesieklpvfnksafkhdwc