PDB entry 2z0p

View 2z0p on RCSB PDB site
Description: Crystal structure of PH domain of Bruton's tyrosine kinase
Class: signaling protein
Keywords: PH domain, PIP3C4, Acetylation, ATP-binding, Cytoplasm, Disease mutation, Kinase, Membrane, Metal-binding, Nucleotide-binding, Nucleus, Phosphorylation, Polymorphism, SH2 domain, SH3 domain, Transferase, Tyrosine-protein kinase, Zinc, Zinc-finger, SIGNALING PROTEIN, Structural Genomics, NPPSFA, National Project on Protein Structural and Functional Analyses, RIKEN Structural Genomics/Proteomics Initiative, RSGI
Deposited on 2007-05-07, released 2008-05-13
The last revision prior to the SCOPe 2.05 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 2.58 Å
R-factor: 0.242
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase BTK
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d2z0pa_
  • Chain 'B':
    Compound: Tyrosine-protein kinase BTK
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d2z0pb_
  • Chain 'C':
    Compound: Tyrosine-protein kinase BTK
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d2z0pc_
  • Chain 'D':
    Compound: Tyrosine-protein kinase BTK
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d2z0pd_
  • Heterogens: ZN, 4PT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2z0pA (A:)
aavilesiflkrsqqkkktsplnfkkrlflltvhklsyyeydfergrrgskkgsidveki
tcvetvvpeknppperqiprrgeessemeqisiierfpypfqvvydegplyvfspteelr
krwihqlknvirynsdlvqkyhpcfwidgqylccsqtaknamgcqilen

    Sequence, based on observed residues (ATOM records): (download) 
    >2z0pA (A:)
aavilesiflkrsqqkkktsplnfkkrlflltvhklsyyeydfergrrgskkgsidveki
tcvetvvpeknppperqimeqisiierfpypfqvvydegplyvfspteelrkrwihqlkn
virynsdlvqkyhpcfwidgqylccsqtaknamgcqil

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2z0pB (B:)
aavilesiflkrsqqkkktsplnfkkrlflltvhklsyyeydfergrrgskkgsidveki
tcvetvvpeknppperqiprrgeessemeqisiierfpypfqvvydegplyvfspteelr
krwihqlknvirynsdlvqkyhpcfwidgqylccsqtaknamgcqilen

    Sequence, based on observed residues (ATOM records): (download) 
    >2z0pB (B:)
aavilesiflkrsqqkkktsplnfkkrlflltvhklsyyeydfergrrgskkgsidveki
tcvetvvpeknppperqiemeqisiierfpypfqvvydegplyvfspteelrkrwihqlk
nvirynsdlvqkyhpcfwidgqylccsqtaknamgcqilen

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2z0pC (C:)
aavilesiflkrsqqkkktsplnfkkrlflltvhklsyyeydfergrrgskkgsidveki
tcvetvvpeknppperqiprrgeessemeqisiierfpypfqvvydegplyvfspteelr
krwihqlknvirynsdlvqkyhpcfwidgqylccsqtaknamgcqilen

    Sequence, based on observed residues (ATOM records): (download) 
    >2z0pC (C:)
aavilesiflkrsqqklnfkkrlflltvhklsyyeydfergrrgskkgsidvekitcvet
vvpeknppperqimeqisiierfpypfqvvydegplyvfspteelrkrwihqlknviryn
sdlvqkyhpcfwidgqylccsqtaknamgcqilen

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2z0pD (D:)
aavilesiflkrsqqkkktsplnfkkrlflltvhklsyyeydfergrrgskkgsidveki
tcvetvvpeknppperqiprrgeessemeqisiierfpypfqvvydegplyvfspteelr
krwihqlknvirynsdlvqkyhpcfwidgqylccsqtaknamgcqilen

    Sequence, based on observed residues (ATOM records): (download) 
    >2z0pD (D:)
aavilesiflkrsqqkkktsplnfkkrlflltvhklsyyeydfergrrgskkgsidveki
tcvetvvpeknppperqipmeqisiierfpypfqvvydegplyvfspteelrkrwihqlk
nvirynsdlvqkyhpcfwidgqylccsqtaknamgcqilen