PDB entry 2yza

View 2yza on RCSB PDB site
Description: Crystal structure of kinase domain of Human 5'-AMP-activated protein kinase alpha-2 subunit mutant (T172D)
Class: Transferase
Keywords: Signaling protein, Serine/threonine protein kinase, Phosphorylation, ATP-binding, Nucleotide-binding, Cholesterol biosynthesis, Fatty acid biosynthesis, Lipid synthesis, glucose metabolism, Magnesium, Metal-binding, Serine/threonine-protein kinase, Steroid biosynthesis, Transferase, Structural Genomics, NPPSFA, National Project on Protein Structural and Functional Analyses, RIKEN Structural Genomics/Proteomics Initiative, RSGI
Deposited on 2007-05-04, released 2008-05-06
The last revision prior to the SCOPe 2.08 freeze date was dated 2012-04-11, with a file datestamp of 2012-04-06.
Experiment type: XRAY
Resolution: 3.02 Å
R-factor: 0.235
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: 5'-AMP-activated protein kinase catalytic subunit alpha-2
  Species: Homo sapiens [TaxId:9606]
  Gene: PRKAA2, AMPK, AMPK2
  Database cross-references and differences (RAF-indexed):
  • Uniprot P54646
  Domains in SCOPe 2.08: d2yzaa_
• Heterogens: HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence, based on SEQRES records: (download)
  

  >2yzaA (A:)
  gskhdgrvkighyvlgdtlgvgtfgkvkigehqltghkvavkilnrqkirsldvvgkikr
  eiqnlklfrhphiiklyqvistptdffmvmeyvsggelfdyickhgrveemearrlfqqi
  lsavdychrhmvvhrdlkpenvlldahmnakiadfglsnmmsdgeflrdscgspnyaape
  visgrlyagpevdiwscgvilyallcgtlpfddehvptlfkkirggvfyipeylnrsvat
  llmhmlqvdplkratikdirehewfkqdlpsylfpe
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >2yzaA (A:)
  rvkighyvlgdtlgvgtfgkvkigehqltghkvavkilnrqkirsldvvgkikreiqnlk
  lfrhphiiklyqvistptdffmvmeyvsggelfdyickhgrveemearrlfqqilsavdy
  chrhmvvhrdlkpenvlldahmnakiadfglsnmmsdnyaapevisgrlyagpevdiwsc
  gvilyallcgtlpfddehvptlfkkirggvfyipeylnrsvatllmhmlqvdplkratik
  direhewfkqdlpsylfp