PDB entry 2yxj

View 2yxj on RCSB PDB site
Description: Crystal structure of Bcl-xL in complex with ABT-737
Class: apoptosis
Keywords: apoptosis, cancer therapeutic
Deposited on 2007-04-26, released 2007-05-22
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.201
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: apoptosis regulator bcl-x
    Species: Homo sapiens [TaxId:9606]
    Gene: BCL-XL
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d2yxja_
  • Chain 'B':
    Compound: apoptosis regulator bcl-x
    Species: Homo sapiens [TaxId:9606]
    Gene: BCL-XL
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d2yxjb_
  • Heterogens: CL, N3C, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2yxjA (A:)
msmamsqsnrelvvdflsyklsqkgyswsqfsdveenrteapegteseavkqalreagde
felryrrafsdltsqlhitpgtayqsfeqvvnelfrdgvnwgrivaffsfggalcvesvd
kemqvlvsriaawmatylndhlepwiqenggwdtfvelygnnaaaesrkgqerlehhhhh
h

    Sequence, based on observed residues (ATOM records): (download) 
    >2yxjA (A:)
snrelvvdflsyklsqkgyswsseavkqalreagdefelryrrafsdltsqlhitpgtay
qsfeqvvnelfrdgvnwgrivaffsfggalcvesvdkemqvlvsriaawmatylndhlep
wiqenggwdtfvelygn

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2yxjB (B:)
msmamsqsnrelvvdflsyklsqkgyswsqfsdveenrteapegteseavkqalreagde
felryrrafsdltsqlhitpgtayqsfeqvvnelfrdgvnwgrivaffsfggalcvesvd
kemqvlvsriaawmatylndhlepwiqenggwdtfvelygnnaaaesrkgqerlehhhhh
h

    Sequence, based on observed residues (ATOM records): (download) 
    >2yxjB (B:)
sqsnrelvvdflsyklsqkgyswsqfsdseavkqalreagdefelryrrafsdltsqlhi
tpgtayqsfeqvvnelfrdgvnwgrivaffsfggalcvesvdkemqvlvsriaawmatyl
ndhlepwiqenggwdtfvelyg