PDB entry 2ypu

View 2ypu on RCSB PDB site
Description: human insulin degrading enzyme E111Q in complex with inhibitor compound 41367
Deposited on 2012-11-01, released 2012-11-28
The last revision was dated 2014-04-30, with a file datestamp of 2014-04-25.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.17522
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Insulin-degrading enzyme
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14735
      • engineered mutation (80-81)
      • engineered mutation (141)
      • engineered mutation (148)
      • engineered mutation (227)
      • engineered mutation (384)
      • engineered mutation (543)
      • engineered mutation (560)
      • engineered mutation (759)
      • engineered mutation (782)
      • engineered mutation (789)
      • engineered mutation (874)
  • Chain 'B':
    Compound: Insulin-degrading enzyme
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14735
      • engineered mutation (80-81)
      • engineered mutation (141)
      • engineered mutation (148)
      • engineered mutation (227)
      • engineered mutation (384)
      • engineered mutation (543)
      • engineered mutation (560)
      • engineered mutation (759)
      • engineered mutation (782)
      • engineered mutation (789)
      • engineered mutation (874)
  • Heterogens: ZN, I41, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >2ypuA (A:)
mhhhhhhaagipmnnpaikrignhitkspedkreyrglelangikvllisdpttdkssaa
ldvhigslsdppniaglshflqhmlflgtkkypkeneysqflsehagssnaftsgehtny
yfdvshehlegaldrfaqfflsplfdesakdrevnavdseheknvmndawrlfqlekatg
npkhpfskfgtgnkytletrpnqegidvrqellkfhsayyssnlmavvvlgreslddltn
lvvklfsevenknvplpefpehpfqeehlkqlykivpikdirnlyvtfpipdlqkyyksn
pghylghlighegpgsllselkskgwvntlvggqkegargfmffiinvdlteegllhved
iilhmfqyiqklraegpqewvfqelkdlnavafrfkdkerprgytskiagilhyypleev
ltaeylleefrpdliemvldklrpenvrvaivsksfegktdrteewygtqykqeaipdev
ikkwqnadlngkfklptknefiptnfeilplekeatpypalikdtamsklwfkqddkffl
pkanlnfeffspfayvdplhsnmaylylellkdslneyayaaelaglsydlqntiygmyl
svkgyndkqpillkkiiekmatfeidekrfeiikeaymrslnnfraeqphqhamyylrll
mtevawtkdelkealddvtlprlkafipqllsrlhieallhgnitkqaalgimqmvedtl
iehahtkpllpsqlvryrevqlpdrgwfvyqqrnevhnnsgieiyyqtdmqstsenmfle
lfaqiisepafntlrtkeqlgyivfsgprrangiqglrfiiqsekpphylesrveaflit
meksiedmteeafqkhiqalairrldkpkklsaesakywgeiisqqynfdrdntevaylk
tltkediikfykemlavdaprrhkvsvhvlaremdsnpvvgefpaqndinlsqapalpqp
eviqnmtefkrglplfplvkphinfmaakl

    Sequence, based on observed residues (ATOM records):
    >2ypuA (A:)
nnpaikrignhitkspedkreyrglelangikvllisdpttdkssaaldvhigslsdppn
iaglshflqhmlflgtkkypkeneysqflsehagssnaftsgehtnyyfdvshehlegal
drfaqfflsplfdesakdrevnavdseheknvmndawrlfqlekatgnpkhpfskfgtgn
kytletrpnqegidvrqellkfhsayyssnlmavvvlgreslddltnlvvklfsevenkn
vplpefpehpfqeehlkqlykivpikdirnlyvtfpipdlqkyyksnpghylghligheg
pgsllselkskgwvntlvggqkegargfmffiinvdlteegllhvediilhmfqyiqklr
aegpqewvfqelkdlnavafrfkdkerprgytskiagilhyypleevltaeylleefrpd
liemvldklrpenvrvaivsksfegktdrteewygtqykqeaipdevikkwqnadlngkf
klptknefiptnfeilplekeatpypalikdtamsklwfkqddkfflpkanlnfeffspf
ayvdplhsnmaylylellkdslneyayaaelaglsydlqntiygmylsvkgyndkqpill
kkiiekmatfeidekrfeiikeaymrslnnfraeqphqhamyylrllmtevawtkdelke
alddvtlprlkafipqllsrlhieallhgnitkqaalgimqmvedtliehahtkpllpsq
lvryrevqlpdrgwfvyqqrnevhnnsgieiyyqtdmqstsenmflelfaqiisepafnt
lrtkeqlgyivfsgprrangiqglrfiiqsekpphylesrveaflitmeksiedmteeaf
qkhiqalairrldkpkklsaesakywgeiisqqynfdrdntevaylktltkediikfyke
mlavdaprrhkvsvhvlaremdinlsqapalpqpeviqnmtefkrglplfplvkph

  • Chain 'B':
    Sequence, based on SEQRES records:
    >2ypuB (B:)
mhhhhhhaagipmnnpaikrignhitkspedkreyrglelangikvllisdpttdkssaa
ldvhigslsdppniaglshflqhmlflgtkkypkeneysqflsehagssnaftsgehtny
yfdvshehlegaldrfaqfflsplfdesakdrevnavdseheknvmndawrlfqlekatg
npkhpfskfgtgnkytletrpnqegidvrqellkfhsayyssnlmavvvlgreslddltn
lvvklfsevenknvplpefpehpfqeehlkqlykivpikdirnlyvtfpipdlqkyyksn
pghylghlighegpgsllselkskgwvntlvggqkegargfmffiinvdlteegllhved
iilhmfqyiqklraegpqewvfqelkdlnavafrfkdkerprgytskiagilhyypleev
ltaeylleefrpdliemvldklrpenvrvaivsksfegktdrteewygtqykqeaipdev
ikkwqnadlngkfklptknefiptnfeilplekeatpypalikdtamsklwfkqddkffl
pkanlnfeffspfayvdplhsnmaylylellkdslneyayaaelaglsydlqntiygmyl
svkgyndkqpillkkiiekmatfeidekrfeiikeaymrslnnfraeqphqhamyylrll
mtevawtkdelkealddvtlprlkafipqllsrlhieallhgnitkqaalgimqmvedtl
iehahtkpllpsqlvryrevqlpdrgwfvyqqrnevhnnsgieiyyqtdmqstsenmfle
lfaqiisepafntlrtkeqlgyivfsgprrangiqglrfiiqsekpphylesrveaflit
meksiedmteeafqkhiqalairrldkpkklsaesakywgeiisqqynfdrdntevaylk
tltkediikfykemlavdaprrhkvsvhvlaremdsnpvvgefpaqndinlsqapalpqp
eviqnmtefkrglplfplvkphinfmaakl

    Sequence, based on observed residues (ATOM records):
    >2ypuB (B:)
nnpaikrignhitkspedkreyrglelangikvllisdpttdkssaaldvhigslsdppn
iaglshflqhmlflgtkkypkeneysqflsehagssnaftsgehtnyyfdvshehlegal
drfaqfflsplfdesakdrevnavdseheknvmndawrlfqlekatgnpkhpfskfgtgn
kytletrpnqegidvrqellkfhsayyssnlmavvvlgreslddltnlvvklfsevenkn
vplpefpehpfqeehlkqlykivpikdirnlyvtfpipdlqkyyksnpghylghligheg
pgsllselkskgwvntlvggqkegargfmffiinvdlteegllhvediilhmfqyiqklr
aegpqewvfqelkdlnavafrfkdkerprgytskiagilhyypleevltaeylleefrpd
liemvldklrpenvrvaivsksfegktdrteewygtqykqeaipdevikkwqnadlngkf
klptknefiptnfeilplekeatpypalikdtamsklwfkqddkfflpkanlnfeffspf
ayvdplhsnmaylylellkdslneyayaaelaglsydlqntiygmylsvkgyndkqpill
kkiiekmatfeidekrfeiikeaymrslnnfraeqphqhamyylrllmtevawtkdelke
alddvtlprlkafipqllsrlhieallhgnitkqaalgimqmvedtliehahtkpllpsq
lvryrevqlpdrgwfvyqqrnevhnnsgieiyyqtdmqstsenmflelfaqiisepafnt
lrtkeqlgyivfsgprrangiqglrfiiqsekpphylesrveaflitmeksiedmteeaf
qkhiqalairrldkpkklsaesakywgeiisqqynfdrdntevaylktltkediikfyke
mlavdaprrhkvsvhvlaremdlsqapalpqpeviqnmtefkrglplfplvkph