PDB entry 2yni

View 2yni on RCSB PDB site
Description: HIV-1 Reverse Transcriptase in complex with inhibitor GSK952
Class: hydrolase
Keywords: hydrolase, nnrti
Deposited on 2012-10-15, released 2013-01-09
The last revision prior to the SCOPe 2.08 freeze date was dated 2013-12-18, with a file datestamp of 2013-12-13.
Experiment type: XRAY
Resolution: 2.49 Å
R-factor: 0.2037
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Reverse transcriptase/ribonuclease H
    Species: HIV-1 M:B_HXB2R [TaxId:11706]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04585 (3-End)
      • expression tag (1-2)
    Domains in SCOPe 2.08: d2ynia1, d2ynia2, d2ynia3
  • Chain 'B':
    Compound: p51 RT
    Species: HIV-1 M:B_HXB2R [TaxId:11706]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2ynib_
  • Heterogens: MG, TAR, CXD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2yniA (A:)
mnspispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyn
tpvfaikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfs
vpldedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpd
iviyqymddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpd
kwtvqpivlpekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplte
eaelelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarm
rgahtndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefv
ntpplvklwyqlekepivgaetfyvdgaanretklgkagyvtnrgrqkvvtltdttnqkt
elqaiylalqdsglevnivtdsqyalgiiqaqpdqseselvnqiieqlikkekvylawvp
ahkgiggneqvdklvsagirkvl

    Sequence, based on observed residues (ATOM records): (download) 
    >2yniA (A:)
nspispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpynt
pvfaikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsv
pldedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdi
viyqymddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdk
wtvqpivlpekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkaltevipltee
aelelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmr
gahtndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvn
tpplvklwyqlekepivgaetfyvdgaanretklgkagyvtnrgrqkvvtltdttnqkte
lqaiylalqdsglevnivtdsqyalgiiqaqpdqseselvnqiieqlikkekvylawvpa
hkgiggneqvdklvsagirk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2yniB (B:)
maghhhhhhgsaenlyfqgpispietvpvklkpgmdgpkvkqwplteekikalveictem
ekegkiskigpenpyntpvfaikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglk
kkksvtvldvgdayfsvpldedfrkytaftipsinnetpgiryqynvlpqgwkgspaifq
ssmtkilepfrkqnpdiviyqymddlyvgsdleigqhrtkieelrqhllrwglttpdkkh
qkeppflwmgyelhpdkwtvqpivlpekdswtvndiqklvgklnwasqiypgikvrqlck
llrgtkalteviplteeaelelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqi
yqepfknlktgkyarmrgahtndvkqlteavqkittesiviwgktpkfklpiqketwetw
wteywqatwipewefvntpplvklwyq

    Sequence, based on observed residues (ATOM records): (download) 
    >2yniB (B:)
ietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaik
kstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpldedfrk
ytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqymdd
lyvgsdleigqhrtkieelrqhllrwgltwmgyelhpdkwtvqpivlpekdswtvndiqk
lvgklnwasqiypgikvrqlckllrgtkalteviplteeaelelaenreilkepvhgvyy
dpskdliaeiqkqgqgqwtyqiyqepfknlktgkyartndvkqlteavqkittesiviwg
ktpkfklpiqketwetwwteywqatwipewefvntpplvklwyq