PDB entry 2ynf

View 2ynf on RCSB PDB site
Description: HIV-1 Reverse Transcriptase Y188L mutant in complex with inhibitor GSK560
Class: hydrolase
Keywords: hydrolase, nnrti
Deposited on 2012-10-14, released 2013-01-09
The last revision prior to the SCOPe 2.08 freeze date was dated 2013-01-09, with a file datestamp of 2013-01-04.
Experiment type: XRAY
Resolution: 2.36 Å
R-factor: 0.1984
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Reverse transcriptase/ribonuclease H
    Species: HIV-1 M:B_HXB2R [TaxId:11706]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04585 (3-End)
      • expression tag (1-2)
      • engineered mutation (190)
    Domains in SCOPe 2.08: d2ynfa1, d2ynfa2, d2ynfa3
  • Chain 'B':
    Compound: p51 RT
    Species: HIV-1 M:B_HXB2R [TaxId:11706]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2ynfb_
  • Heterogens: MG, TAR, WHU, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2ynfA (A:)
mnspispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyn
tpvfaikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfs
vpldedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpd
iviyqymddllvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpd
kwtvqpivlpekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplte
eaelelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarm
rgahtndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefv
ntpplvklwyqlekepivgaetfyvdgaanretklgkagyvtnrgrqkvvtltdttnqkt
elqaiylalqdsglevnivtdsqyalgiiqaqpdqseselvnqiieqlikkekvylawvp
ahkgiggneqvdklvsagirkvl

    Sequence, based on observed residues (ATOM records): (download) 
    >2ynfA (A:)
nspispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpynt
pvfaikstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpld
edfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviy
qymddllvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwtv
qpivlpekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeael
elaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgah
tndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpp
lvklwyqlekepivgaetfyvdgaanretklgkagyvtnrgrqkvvtltdttnqktelqa
iylalqdsglevnivtdsqyalgiiqaqpdqseselvnqiieqlikkekvylawvpahkg
iggneqvdklvsagirk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2ynfB (B:)
maghhhhhhgsaenlyfqgpispietvpvklkpgmdgpkvkqwplteekikalveictem
ekegkiskigpenpyntpvfaikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglk
kkksvtvldvgdayfsvpldedfrkytaftipsinnetpgiryqynvlpqgwkgspaifq
ssmtkilepfrkqnpdiviyqymddlyvgsdleigqhrtkieelrqhllrwglttpdkkh
qkeppflwmgyelhpdkwtvqpivlpekdswtvndiqklvgklnwasqiypgikvrqlck
llrgtkalteviplteeaelelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqi
yqepfknlktgkyarmrgahtndvkqlteavqkittesiviwgktpkfklpiqketwetw
wteywqatwipewefvntpplvklwyq

    Sequence, based on observed residues (ATOM records): (download) 
    >2ynfB (B:)
etvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaikk
kdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpldedfr
kytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqymd
dlyvgsdleigqhrtkieelrqhllrwglttwmgyelhpdkwtvqpivlpekdswtvndi
qklvgklnwasqiypgikvrqlckllrgtkalteviplteeaelelaenreilkepvhgv
yydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyartndvkqlteavqkittesivi
wgktpkfklpiqketwetwwteywqatwipewefvntpplvklwyq