PDB entry 2yfx

View 2yfx on RCSB PDB site
Description: Structure of L1196M Mutant Anaplastic Lymphoma Kinase in Complex with Crizotinib
Class: transferase
Keywords: nucleotide-binding, transferase, receptor
Deposited on 2011-04-08, released 2011-05-04
The last revision prior to the SCOPe 2.05 freeze date was dated 2014-03-19, with a file datestamp of 2014-03-14.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: 0.208
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: tyrosine-protein kinase receptor
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot B6EXY4 (8-End)
      • engineered mutation (111)
    Domains in SCOPe 2.05: d2yfxa_
  • Heterogens: VGH, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2yfxA (A:)
mahhhhhhnpnycfagktssisdlkevprknitlirglghgafgevyegqvsgmpndpsp
lqvavktlpevcseqdeldflmealiiskfnhqnivrcigvslqslprfilmelmaggdl
ksflretrprpsqpsslamldllhvardiacgcqyleenhfihrdiaarnclltcpgpgr
vakigdfgmardiyrasyyrkggcamlpvkwmppeafmegiftsktdtwsfgvllweifs
lgympypsksnqevlefvtsggrmdppkncpgpvyrimtqcwqhqpedrpnfaiilerie
yctqdpdvintalpieygplveeeekv

    Sequence, based on observed residues (ATOM records): (download) 
    >2yfxA (A:)
npnycfagktssisdlkevprknitlirglgafgevyegqvplqvavktlpevcseqdel
dflmealiiskfnhqnivrcigvslqslprfilmelmaggdlksflretrprpsqpssla
mldllhvardiacgcqyleenhfihrdiaarnclltcpgpgrvakigdfgmardiyrggc
amlpvkwmppeafmegiftsktdtwsfgvllweifslgympypsksnqevlefvtsggrm
dppkncpgpvyrimtqcwqhqpedrpnfaiilerieyctqdpdvintalpiey