PDB entry 2yfx
View 2yfx on RCSB PDB site
Description: Structure of L1196M Mutant Anaplastic Lymphoma Kinase in Complex with Crizotinib
Class: transferase
Keywords: nucleotide-binding, transferase, receptor
Deposited on
2011-04-08, released
2011-05-04
The last revision prior to the SCOPe 2.08 freeze date was dated
2019-05-08, with a file datestamp of
2019-05-03.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: N/A
AEROSPACI score: 0.41
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: tyrosine-protein kinase receptor
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot B6EXY4 (8-End)
- engineered mutation (111)
Domains in SCOPe 2.08: d2yfxa_ - Heterogens: VGH, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2yfxA (A:)
mahhhhhhnpnycfagktssisdlkevprknitlirglghgafgevyegqvsgmpndpsp
lqvavktlpevcseqdeldflmealiiskfnhqnivrcigvslqslprfilmelmaggdl
ksflretrprpsqpsslamldllhvardiacgcqyleenhfihrdiaarnclltcpgpgr
vakigdfgmardiyrasyyrkggcamlpvkwmppeafmegiftsktdtwsfgvllweifs
lgympypsksnqevlefvtsggrmdppkncpgpvyrimtqcwqhqpedrpnfaiilerie
yctqdpdvintalpieygplveeeekv
Sequence, based on observed residues (ATOM records): (download)
>2yfxA (A:)
npnycfagktssisdlkevprknitlirglgafgevyegqvplqvavktlpevcseqdel
dflmealiiskfnhqnivrcigvslqslprfilmelmaggdlksflretrprpsqpssla
mldllhvardiacgcqyleenhfihrdiaarnclltcpgpgrvakigdfgmardiyrggc
amlpvkwmppeafmegiftsktdtwsfgvllweifslgympypsksnqevlefvtsggrm
dppkncpgpvyrimtqcwqhqpedrpnfaiilerieyctqdpdvintalpiey