PDB entry 2yem
View 2yem on RCSB PDB site
Description: Crystal Structure of the Second Bromodomain of Human Brd4 with the inhibitor GW841819X
Class: signaling protein
Keywords: signaling protein, histone, epigenetic reader
Deposited on
2011-03-25, released
2011-06-15
The last revision prior to the SCOPe 2.06 freeze date was dated
2013-05-08, with a file datestamp of
2013-05-03.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.18246
AEROSPACI score: 0.41
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Bromodomain-containing protein 4
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d2yema_ - Chain 'B':
Compound: Bromodomain-containing protein 4
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d2yemb_ - Heterogens: WSH, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2yemA (A:)
smkdvpdsqqhpapeksskvseqlkccsgilkemfakkhaayawpfykpvdvealglhdy
cdiikhpmdmstikskleareyrdaqefgadvrlmfsncykynppdhevvamarklqdvf
emrfakmpde
Sequence, based on observed residues (ATOM records): (download)
>2yemA (A:)
kvseqlkccsgilkemfakkhaayawpfykpvdvealglhdycdiikhpmdmstikskle
areyrdaqefgadvrlmfsncykynppdhevvamarklqdvfemrfakmp
- Chain 'B':
Sequence, based on SEQRES records: (download)
>2yemB (B:)
smkdvpdsqqhpapeksskvseqlkccsgilkemfakkhaayawpfykpvdvealglhdy
cdiikhpmdmstikskleareyrdaqefgadvrlmfsncykynppdhevvamarklqdvf
emrfakmpde
Sequence, based on observed residues (ATOM records): (download)
>2yemB (B:)
kvseqlkccsgilkemfakkhaayawpfykpvdvealglhdycdiikhpmdmstikskle
areyrdaqefgadvrlmfsncykynppdhevvamarklqdvfemrfakmpd