PDB entry 2ydw

View 2ydw on RCSB PDB site
Description: Crystal Structure of the First Bromodomain of Human Brd2 with the inhibitor GW841819X
Class: nuclear protein
Keywords: nuclear protein, histone, epigenetic reader
Deposited on 2011-03-24, released 2011-06-15
The last revision prior to the SCOPe 2.08 freeze date was dated 2012-11-21, with a file datestamp of 2012-11-16.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.20247
AEROSPACI score: 0.48 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Bromodomain-containing protein 2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2ydwa_
  • Chain 'B':
    Compound: Bromodomain-containing protein 2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2ydwb_
  • Chain 'C':
    Compound: Bromodomain-containing protein 2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2ydwc_
  • Heterogens: WSH, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2ydwA (A:)
gsshhhhhhssglvprgshmsnpkkpgrvtnqlqylhkvvmkalwkhqfawpfrqpvdav
klglpdyhkiikqpmdmgtikrrlennyywaasecmqdfntmftncyiynkptddivlma
qtlekiflqkvasmpqeeqelvvtipnshkkga

    Sequence, based on observed residues (ATOM records): (download) 
    >2ydwA (A:)
tnqlqylhkvvmkalwkhqfawpfrqpvdavklglpdyhkiikqpmdmgtikrrlennyy
waasecmqdfntmftncyiynkptddivlmaqtlekiflqkvasmpq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2ydwB (B:)
gsshhhhhhssglvprgshmsnpkkpgrvtnqlqylhkvvmkalwkhqfawpfrqpvdav
klglpdyhkiikqpmdmgtikrrlennyywaasecmqdfntmftncyiynkptddivlma
qtlekiflqkvasmpqeeqelvvtipnshkkga

    Sequence, based on observed residues (ATOM records): (download) 
    >2ydwB (B:)
nqlqylhkvvmkalwkhqfawpfrqpvdavklglpdyhkiikqpmdmgtikrrlennyyw
aasecmqdfntmftncyiynkptddivlmaqtlekiflqkvasmp

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2ydwC (C:)
gsshhhhhhssglvprgshmsnpkkpgrvtnqlqylhkvvmkalwkhqfawpfrqpvdav
klglpdyhkiikqpmdmgtikrrlennyywaasecmqdfntmftncyiynkptddivlma
qtlekiflqkvasmpqeeqelvvtipnshkkga

    Sequence, based on observed residues (ATOM records): (download) 
    >2ydwC (C:)
tnqlqylhkvvmkalwkhqfawpfrqpvdavklglpdyhkiikqpmdmgtikrrlennyy
waasecmqdfntmftncyiynkptddivlmaqtlekiflqkvasmpq