PDB entry 2yb3

View 2yb3 on RCSB PDB site
Description: Structure of Insulin Degrading Enzyme with compound (41367)
Deposited on 2011-02-28, released 2012-03-21
The last revision was dated 2012-11-28, with a file datestamp of 2012-11-23.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.17522
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Insulin-degrading enzyme
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14735 (0-968)
      • engineered mutation (67)
      • engineered mutation (128)
      • engineered mutation (135)
      • engineered mutation (214)
      • engineered mutation (371)
      • engineered mutation (530)
      • engineered mutation (547)
      • engineered mutation (746)
      • engineered mutation (769)
      • engineered mutation (776)
      • engineered mutation (861)
  • Chain 'B':
    Compound: Insulin-degrading enzyme
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14735 (0-968)
      • engineered mutation (67)
      • engineered mutation (128)
      • engineered mutation (135)
      • engineered mutation (214)
      • engineered mutation (371)
      • engineered mutation (530)
      • engineered mutation (547)
      • engineered mutation (746)
      • engineered mutation (769)
      • engineered mutation (776)
      • engineered mutation (861)
  • Heterogens: ZN, I41, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >2yb3A (A:)
nnpaikrignhitkspedkreyrglelangikvllisdpttdkssaaldvhigslsdppn
iaglshflehmlflgtkkypkeneysqflsehagssnaftsgehtnyyfdvshehlegal
drfaqfflsplfdesakdrevnavdseheknvmndawrlfqlekatgnpkhpfskfgtgn
kytletrpnqegidvrqellkfhsayyssnlmavvvlgreslddltnlvvklfsevenkn
vplpefpehpfqeehlkqlykivpikdirnlyvtfpipdlqkyyksnpghylghligheg
pgsllselkskgwvntlvggqkegargfmffiinvdlteegllhvediilhmfqyiqklr
aegpqewvfqelkdlnavafrfkdkerprgytskiagilhyypleevltaeylleefrpd
liemvldklrpenvrvaivsksfegktdrteewygtqykqeaipdevikkwqnadlngkf
klptknefiptnfeilplekeatpypalikdtamsklwfkqddkfflpkanlnfeffspf
ayvdplhsnmaylylellkdslneyayaaelaglsydlqntiygmylsvkgyndkqpill
kkiiekmatfeidekrfeiikeaymrslnnfraeqphqhamyylrllmtevawtkdelke
alddvtlprlkafipqllsrlhieallhgnitkqaalgimqmvedtliehahtkpllpsq
lvryrevqlpdrgwfvyqqrnevhnnsgieiyyqtdmqstsenmflelfaqiisepafnt
lrtkeqlgyivfsgprrangiqglrfiiqsekpphylesrveaflitmeksiedmteeaf
qkhiqalairrldkpkklsaesakywgeiisqqynfdrdntevaylktltkediikfyke
mlavdaprrhkvsvhvlaremdsnpvvgefpaqndinlsqapalpqpeviqnmtefkrgl
plfplvkph

    Sequence, based on observed residues (ATOM records):
    >2yb3A (A:)
nnpaikrignhitkspedkreyrglelangikvllisdpttdkssaaldvhigslsdppn
iaglshflehmlflgtkkypkeneysqflsehagssnaftsgehtnyyfdvshehlegal
drfaqfflsplfdesakdrevnavdseheknvmndawrlfqlekatgnpkhpfskfgtgn
kytletrpnqegidvrqellkfhsayyssnlmavvvlgreslddltnlvvklfsevenkn
vplpefpehpfqeehlkqlykivpikdirnlyvtfpipdlqkyyksnpghylghligheg
pgsllselkskgwvntlvggqkegargfmffiinvdlteegllhvediilhmfqyiqklr
aegpqewvfqelkdlnavafrfkdkerprgytskiagilhyypleevltaeylleefrpd
liemvldklrpenvrvaivsksfegktdrteewygtqykqeaipdevikkwqnadlngkf
klptknefiptnfeilplekeatpypalikdtamsklwfkqddkfflpkanlnfeffspf
ayvdplhsnmaylylellkdslneyayaaelaglsydlqntiygmylsvkgyndkqpill
kkiiekmatfeidekrfeiikeaymrslnnfraeqphqhamyylrllmtevawtkdelke
alddvtlprlkafipqllsrlhieallhgnitkqaalgimqmvedtliehahtkpllpsq
lvryrevqlpdrgwfvyqqrnevhnnsgieiyyqtdmqstsenmflelfaqiisepafnt
lrtkeqlgyivfsgprrangiqglrfiiqsekpphylesrveaflitmeksiedmteeaf
qkhiqalairrldkpkklsaesakywgeiisqqynfdrdntevaylktltkediikfyke
mlavdaprrhkvsvhvlaremdinlsqapalpqpeviqnmtefkrglplfplvkph

  • Chain 'B':
    Sequence, based on SEQRES records:
    >2yb3B (B:)
nnpaikrignhitkspedkreyrglelangikvllisdpttdkssaaldvhigslsdppn
iaglshflehmlflgtkkypkeneysqflsehagssnaftsgehtnyyfdvshehlegal
drfaqfflsplfdesakdrevnavdseheknvmndawrlfqlekatgnpkhpfskfgtgn
kytletrpnqegidvrqellkfhsayyssnlmavvvlgreslddltnlvvklfsevenkn
vplpefpehpfqeehlkqlykivpikdirnlyvtfpipdlqkyyksnpghylghligheg
pgsllselkskgwvntlvggqkegargfmffiinvdlteegllhvediilhmfqyiqklr
aegpqewvfqelkdlnavafrfkdkerprgytskiagilhyypleevltaeylleefrpd
liemvldklrpenvrvaivsksfegktdrteewygtqykqeaipdevikkwqnadlngkf
klptknefiptnfeilplekeatpypalikdtamsklwfkqddkfflpkanlnfeffspf
ayvdplhsnmaylylellkdslneyayaaelaglsydlqntiygmylsvkgyndkqpill
kkiiekmatfeidekrfeiikeaymrslnnfraeqphqhamyylrllmtevawtkdelke
alddvtlprlkafipqllsrlhieallhgnitkqaalgimqmvedtliehahtkpllpsq
lvryrevqlpdrgwfvyqqrnevhnnsgieiyyqtdmqstsenmflelfaqiisepafnt
lrtkeqlgyivfsgprrangiqglrfiiqsekpphylesrveaflitmeksiedmteeaf
qkhiqalairrldkpkklsaesakywgeiisqqynfdrdntevaylktltkediikfyke
mlavdaprrhkvsvhvlaremdsnpvvgefpaqndinlsqapalpqpeviqnmtefkrgl
plfplvkph

    Sequence, based on observed residues (ATOM records):
    >2yb3B (B:)
nnpaikrignhitkspedkreyrglelangikvllisdpttdkssaaldvhigslsdppn
iaglshflehmlflgtkkypkeneysqflsehagssnaftsgehtnyyfdvshehlegal
drfaqfflsplfdesakdrevnavdseheknvmndawrlfqlekatgnpkhpfskfgtgn
kytletrpnqegidvrqellkfhsayyssnlmavvvlgreslddltnlvvklfsevenkn
vplpefpehpfqeehlkqlykivpikdirnlyvtfpipdlqkyyksnpghylghligheg
pgsllselkskgwvntlvggqkegargfmffiinvdlteegllhvediilhmfqyiqklr
aegpqewvfqelkdlnavafrfkdkerprgytskiagilhyypleevltaeylleefrpd
liemvldklrpenvrvaivsksfegktdrteewygtqykqeaipdevikkwqnadlngkf
klptknefiptnfeilplekeatpypalikdtamsklwfkqddkfflpkanlnfeffspf
ayvdplhsnmaylylellkdslneyayaaelaglsydlqntiygmylsvkgyndkqpill
kkiiekmatfeidekrfeiikeaymrslnnfraeqphqhamyylrllmtevawtkdelke
alddvtlprlkafipqllsrlhieallhgnitkqaalgimqmvedtliehahtkpllpsq
lvryrevqlpdrgwfvyqqrnevhnnsgieiyyqtdmqstsenmflelfaqiisepafnt
lrtkeqlgyivfsgprrangiqglrfiiqsekpphylesrveaflitmeksiedmteeaf
qkhiqalairrldkpkklsaesakywgeiisqqynfdrdntevaylktltkediikfyke
mlavdaprrhkvsvhvlaremdlsqapalpqpeviqnmtefkrglplfplvkph