PDB entry 2y8q

View 2y8q on RCSB PDB site
Description: Structure of the regulatory fragment of mammalian AMPK in complex with one ADP
Class: transferase
Keywords: transferase, ADP, nucleotide-binding
Deposited on 2011-02-09, released 2011-03-16
The last revision prior to the SCOPe 2.07 freeze date was dated 2012-11-28, with a file datestamp of 2012-11-23.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.234
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 5'-amp-activated protein kinase catalytic subunit alpha-1
    Species: Rattus norvegicus [TaxId:10116]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P54645 (18-166)
      • expression tag (15-17)
      • expression tag (167-172)
    Domains in SCOPe 2.07: d2y8qa1, d2y8qa2, d2y8qa3
  • Chain 'B':
    Compound: 5'-amp-activated protein kinase subunit beta-2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d2y8qb_
  • Chain 'E':
    Compound: 5'-amp-activated protein kinase subunit gamma-1
    Species: Rattus norvegicus [TaxId:10116]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d2y8qe1, d2y8qe2
  • Heterogens: ADP, AMP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2y8qA (A:)
    mshhhhhhsglvprgsmawhlgirsqsrpndimaevcraikqldyewkvvnpyylrvrrk
    npvtstfskmslqlyqvdsrtylldfrsiddeiteaksgtatpqrsgsisnyrscqrsds
    daeaqgkpsevsltssvtsldsspvdvaprpgshtieffemcanliknsctvn
    

    Sequence, based on observed residues (ATOM records): (download)
    >2y8qA (A:)
    smawhlgirsqsrpndimaevcraikqldyewkvvnpyylrvrrknpvtstfskmslqly
    qvdsrtylldfrsiddevaprpgshtieffemcanliknsctvn
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >2y8qB (B:)
    mgpygqemyafrseerfksppilpphllqvilnkdtniscdpallpepnhvmlnhlyals
    ikdsvmvlsathrykkkyvttllykpi
    

    Sequence, based on observed residues (ATOM records): (download)
    >2y8qB (B:)
    gqemyafrseerfksppilpphllqvilnkdpnhvmlnhlyalsikdsvmvlsathrykk
    kyvttllykpi
    

  • Chain 'E':
    Sequence, based on SEQRES records: (download)
    >2y8qE (E:)
    mesvaaesapapenehsqetpesnssvyttfmkshrcydliptssklvvfdtslqvkkaf
    falvtngvraaplwdskkqsfvgmltitdfinilhryyksalvqiyeleehkietwrevy
    lqdsfkplvcispnaslfdavsslirnkihrlpvidpesgntlyilthkrilkflklfit
    efpkpefmsksleelqigtyaniamvrtttpvyvalgifvqhrvsalpvvdekgrvvdiy
    skfdvinlaaektynnldvsvtkalqhrshyfegvlkcylhetleaiinrlveaevhrlv
    vvdehdvvkgivslsdilqalvltggekkp
    

    Sequence, based on observed residues (ATOM records): (download)
    >2y8qE (E:)
    snssvyttfmkshrcydliptssklvvfdtslqvkkaffalvtngvraaplwdskkqsfv
    gmltitdfinilhryyksalvqiyeleehkietwrevylqdsfkplvcispnaslfdavs
    slirnkihrlpvidpesgntlyilthkrilkflklfitefpkpefmsksleelqigtyan
    iamvrtttpvyvalgifvqhrvsalpvvdekgrvvdiyskfdvinlaaektynnldvsvt
    kalqhrshyfegvlkcylhetleaiinrlveaevhrlvvvdehdvvkgivslsdilqalv
    ltgg