PDB entry 2y80
View 2y80 on RCSB PDB site
Description: structure and property based design of factor xa inhibitors: pyrrolidin-2-ones with aminoindane and phenylpyrrolidine p4 motifs
Class: blood clotting
Keywords: blood clotting, hydrolase, serine protease, blood coagulation
Deposited on
2011-02-02, released
2011-03-16
The last revision prior to the SCOPe 2.06 freeze date was dated
2011-03-16, with a file datestamp of
2011-03-11.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.1916
AEROSPACI score: 0.49
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: activated factor xa heavy chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d2y80a_ - Chain 'B':
Compound: factor x light chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d2y80b_ - Heterogens: 439, CA, MG, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2y80A (A:)
ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
qeeggeavhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlm
tqktgivsgfgrthekgrqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqeda
cqgdsggphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmktrglpka
kshapevitssplk
Sequence, based on observed residues (ATOM records): (download)
>2y80A (A:)
ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
qeeggeavhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlm
tqktgivsgfgrthekgrqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqeda
cqgdsggphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmktr
- Chain 'B':
Sequence, based on SEQRES records: (download)
>2y80B (B:)
eemkkghlerecmeetcsyeearevfedsdktnefwnkykdgdqcetspcqnqgkckdgl
geytctclegfegkncelftrklcsldngdcdqfcheeqnsvvcscargytladngkaci
ptgpypcgkqtler
Sequence, based on observed residues (ATOM records): (download)
>2y80B (B:)
rklcsldngdcdqfcheeqnsvvcscargytladngkaciptgpypcgkqtle